한빛사논문
- 조회406
Yun-Chu Chen a, Sota Shishikura a, Dana E. Moseson a, Austin J. Ignatovich a, Joshua Lomeo b, Aiden Zhu b, Sarena D. Horava c, Coralie A. Richard d, Kinam Park a,e, Yoon Yeo a,e
aDepartment of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
bDigiM Solution LLC, 500 West Cummings Park, Woburn, MA 01801, USA
cEli Lilly and Company, 450 Kendall Street, Cambridge, MA 02142, USA
dEli Lilly and Company, 893 Delaware Street, Indianapolis, IN 46225, USA
eWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
Corresponding author : Yoon Yeo
Abstract
Sustained local delivery of meloxicam by polymeric structures is desirable for preventing subacute inflammation and biofilm formation following tissue incision or injury. Our previous study demonstrated that meloxicam release from hot-melt extruded (HME) poly(ε-caprolactone) (PCL) matrices could be controlled by adjusting the drug content. Increasing drug content accelerated the drug release as the initial drug release generated a pore network to facilitate subsequent drug dissolution and diffusion. In this study, high-resolution micro-computed tomography (HR μCT) and artificial intelligence (AI) image analysis were used to visualize the microstructure of matrices and simulate the drug release process. The image analysis indicated that meloxicam release from the PCL matrix was primarily driven by diffusion but limited by the amount of infiltrating fluid when drug content was low (i.e., the connectivity of the drug/pore network was poor). Since the drug content is not easy to change when a product has a fixed dose and dimension/geometry, we sought an alternative approach to control the meloxicam release from the PCL matrices. Here, magnesium hydroxide (Mg(OH)2) was employed as a solid porogen in the drug-PCL matrix so that Mg(OH)2 dissolved with time in the aqueous environment creating additional pore networks to facilitate local dissolution and diffusion of meloxicam. PCL matrices were produced with a fixed 30 wt% meloxicam loading and variable Mg(OH)2 loadings from 20 wt% to 50 wt%. The meloxicam release increased in proportion to the Mg(OH)2 content, resulting in almost complete drug release in 14 d from the matrix with 50 wt% Mg(OH)2. The porogen addition is a simple strategy to tune drug release kinetics, applicable to other drug-eluting matrices with similar constraints.
논문정보
- Research article
- 2023년 06월 (BRIC 등록일 2023-07-10)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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