한빛사논문
- 조회358
Mijin Kim 1, Magdalini Panagiotakopoulou 1, Chen Chen 1,2,3, Stephen B. Ruiz 1,2, Karuna Ganesh 1,2, Tuomas Tammela 2,4 & Daniel A. Heller 1,2
1Molecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.
2Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA.
3Tri-Institutional PhD Program in Chemical Biology, Sloan Kettering Institute, New York, NY, USA.
4Cancer Biology and Genetics Program, Sloan Kettering Institute, New York, NY, USA.
Corresponding author : Correspondence to Daniel A. Heller.
Abstract
The interactions among tumour cells, the tumour microenvironment (TME) and non-tumour tissues are of interest to many cancer researchers. Micro-engineering approaches and nanotechnologies are under extensive exploration for modelling these interactions and measuring them in situ and in vivo to investigate therapeutic vulnerabilities in cancer and extend a systemic view of tumour ecosystems. Here we highlight the greatest opportunities for improving the understanding of tumour ecosystems using microfluidic devices, bioprinting or organ-on-a-chip approaches. We also discuss the potential of nanosensors that can transmit information from within the TME or elsewhere in the body to address scientific and clinical questions about changes in chemical gradients, enzymatic activities, metabolic and immune profiles of the TME and circulating analytes. This Review aims to connect the cancer biology and engineering communities, presenting biomedical technologies that may expand the methodologies of the former, while inspiring the latter to develop approaches for interrogating cancer ecosystems.
논문정보
- Review Paper
- 2023년 06월 (BRIC 등록일 2023-07-07)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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