한빛사논문
- 조회1,025
Uikyu Chae 1, Jiwan Woo 2, Yakdol Cho 2, Jeong-Kyu Han 3, Soo Hyun Yang 4, Esther Yang 4, Hyogeun Shin 1, Hyun Kim 4, Hyun-Yong Yu 5, C Justin Lee 6, Il-Joo Cho 1 4 *
1Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
2Research Animal Resource Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
3Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
4Department of Anatomy, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
5School of Electrical Engineering, Korea University, Seoul 02841, Republic of Korea.
6Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Republic of Korea.
*Corresponding author: correspondence to Il-Joo Cho
Abstract
Real-time monitoring of various neurochemicals with high spatial resolution in multiple brain regions in vivo can elucidate neural circuits related to various brain diseases. However, previous systems for monitoring neurochemicals have limitations in observing multiple neurochemicals without crosstalk in real time, and these methods cannot record electrical activity, which is essential for investigating neural circuits. Here, we present a real-time bimodal (RTBM) neural probe that uses monolithically integrated biosensors and multiple shanks to study the connectivity of neural circuits by measuring multiple neurochemicals and electrical neural activity in real time. Using the RTBM probe, we demonstrate concurrent measurements of four neurochemicals-glucose, lactate, choline, and glutamate without cross-talking each other-and electrical activity in real time in vivo. Additionally, we show the functional connectivity between the medial prefrontal cortex and mediodorsal thalamus through the simultaneous measurement of chemical and electrical signals. We expect that our device will contribute to not only elucidating the role of neurochemicals in neural circuits related to brain functions but also developing drugs for various brain diseases related to neurochemicals.
논문정보
- Research article
- 2023년 07월 (BRIC 등록일 2023-07-05)
- 국내 연구진
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