김한준 (고려대학교 약학대학, Terasaki Institute)

한빛사 논문

조회396

고려대학교 약학대학, Terasaki Institute

CV File 596 kb

Adv. Healthc. Mater., 2023 Jun 10;e230155 | https://doi.org/10.1002/adhm.202301551 Injectable, Antibacterial, and Hemostatic Tissue Sealant Hydrogels

Reihaneh Haghniaz,^a,b,c, Hossein Montazerian^_,a,b,c, Atiya Rabbani,^b,c,d, Avijit Baidya,^e,f, BrentUsui,^a,g, Yangzhi Zhu,^a, Maryam Tavafoghi,^b,c, Fazli Wahid,^h, Han-Jun Kim,^a,i*, Amir Sheikhi,j^,k* and Ali Khademhosseini^a*

^aTerasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, California 90024, United States
^bDepartment of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, California 90095, United States
^cCalifornia NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095, United States
^dDepartment of Biotechnology, COMSATS University Islamabad, Islamabad, 45550, Pakistan
^eDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States
^fDepartment of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603203, India
^gFranklin W. Olin College of Engineering, 1000 Olin Way, Needham, Massachusetts 02492, United States
^hDepartment of Biomedical Sciences, Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, 22620, Pakistan
ⁱCollege of Pharmacy, Korea University, Sejong, 30019, Republic of Korea

^*Corresponding authors: HanJun Kim, Ali Khademhosseini, Amir Sheikhi

Abstract

Hemorrhage and bacterial infections are major hurdles in the management of life-threatening surgical wounds. Most bioadhesives for wound closure lack sufficient hemostatic and antibacterial properties. Furthermore, they suffer from weak sealing efficacy, particularly for stretchable organs, such as the lung and bladder. Accordingly, there is an unmet need for mechanically robust hemostatic sealants with simultaneous antibacterial effects. Here, we nanoengineer an injectable, photocrosslinkable, and stretchable hydrogel sealant based on gelatin methacryloyl (GelMA), supplemented with antibacterial zinc ferrite (ZF) nanoparticles and hemostatic silicate nanoplatelets (SNs) for rapid blood coagulation. The hydrogel reduced the in vitro viability of Staphylococcus aureus by more than 90%. The addition of SNs (2% w/v) and ZF nanoparticles (1.5 mg mL^-1 ) to GelMA (20% w/v) improved the burst pressure of perforated ex vivo porcine lungs by more than 40%. Such enhancement translated to ∼250% improvement in the tissue sealing capability compared with a commercial hemostatic sealant, Evicel^® . Furthermore, the hydrogels reduced bleeding by ∼50% in rat bleeding models. The nanoengineered hydrogel may open new translational opportunities for the effective sealing of complex wounds that require mechanical flexibility, infection management, and hemostasis.

논문정보

형식Research article
게재일2023년 06월 (BRIC 등록일 2023-06-30)
연구진국내(교신)+국외 연구진
분야 의약학 > 약학

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