한빛사논문
- 조회377
서울대학교
Suwan Jeon a,1, Young-sun Lee b,1, Seh Ri Oh b,1, Jinseong Jeong b, Dong-Hyun Lee a, Kyoung-Ha So b,c, Nathaniel S. Hwang a,b,c,d
aInterdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul 08826, Republic of Korea
bSchool of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea
cBio-MAX/N-Bio Institute, Institute of Bio-Engineering, Seoul National University, Seoul 08826, Republic of Korea
dInstitute of Engineering Research, Seoul National University, Seoul, 08826, Republic of Korea
1These authors contributed equally to this work.
Corresponding authors : Kyoung-Ha So, Nathaniel S. Hwang
Abstract
The endocrine system, consisting of the hypothalamus, pituitary, endocrine glands, and hormones, plays a critical role in hormone metabolic interactions. The complexity of the endocrine system is a significant obstacle to understanding and treating endocrine disorders. Notably, advances in endocrine organoid generation allow a deeper understanding of the endocrine system by providing better comprehension of molecular mechanisms of pathogenesis. Here, we highlight recent advances in endocrine organoids for a wide range of therapeutic applications, from cell transplantation therapy to drug toxicity screening, combined with development in stem cell differentiation and gene editing technologies. In particular, we provide insights into the transplantation of endocrine organoids to reverse endocrine dysfunctions and progress in developing strategies for better engraftments. We also discuss the gap between preclinical and clinical research. Finally, we provide future perspectives for research on endocrine organoids for the development of more effective treatments for endocrine disorders.
논문정보
- Review Paper
- 2023년 06월 (BRIC 등록일 2023-06-28)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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