한빛사논문
- 조회371
Dohyun Yoo 1, Chang-Hee Whang 1, Jungwoo Hong 2, Dohyeon Kim 1, Monica Celine Prayogo 1, Youngju Son 1, Wonsik Jung 1, Seojung Lee 1, Hee-Seung Lee 2, Sangyong Jon 3
1Korea Advanced Institute of Science and Technology, Biological Sciences, KOREA, REPUBLIC OF.
2Korea Advanced Institute of Science and Technology, Chemistry, KOREA, REPUBLIC OF.
3Korea Advanced Institute of Science and Technology, Department of Biological Sciences, 291 Daehak-ro, Yuseong-gu, 34141, Daejeon, KOREA, REPUBLIC OF.
CORRESPONDING AUTHOR : Sangyong Jon
Abstract
Common medications for treating inflammatory bowel disease (IBD) have limited therapeutic efficacy and severe adverse effects. This underscores the urgent need for novel therapeutic approaches that can effectively target inflamed sites in the gastrointestinal tract upon oral administration, exerting potent therapeutic efficacy while minimizing systemic effects. Here, we report the construction and in vivo therapeutic evaluation of a library of anti-inflammatory glycocalyx-mimicking nanoparticles (designated GlyNPs) in a mouse model of IBD. The anti-inflammatory GlyNP library was created by attaching bilirubin (BR) to a library of glycopolymers composed of random combinations of the five most naturally abundant sugars. Direct in vivo screening of 31 BR-attached anti-inflammatory GlyNPs via oral administration into mice with acute colitis led to identification of a candidate GlyNP capable of targeting macrophages in the inflamed colon and effectively alleviating colitis symptoms. These findings suggest that the BR-attached GlyNP library can be used as a platform to identify anti-inflammatory nanomedicines for various inflammatory diseases.
논문정보
- Research article
- 2023년 06월 (BRIC 등록일 2023-06-30)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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