권정훈 (U.S. National Poultry Research Center, 경북대학교) | 한빛사논문 > 한빛사

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U.S. National Poultry Research Center, 경북대학교

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Emerg. Microbes Infect., Published online: 12 Jun 2023 | https://doi.org/10.1080/22221751.2023.2218945 Diverse infectivity, transmissibility, and pathobiology of clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses in chickens

Jung-Hoon Kwon ^1,2, Kateri Bertran ^1,3,4, Dong-Hun Lee ⁵, Miria Ferreira Criado ^1,6, Lindsay Killmaster ¹, Mary J Pantin-Jackwood ¹, David E Swayne ¹

¹Agricultural Research Service, U.S. Department of Agriculture, U.S. National Poultry Research Center, Athens, GA, USA.
²College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
³Unitat mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Bellaterra, Spain.
⁴IRTA. Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Bellaterra, Spain.
⁵College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
⁶Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.

Correspondence : Dong-Hun Lee

Abstract

Clade 2.3.4.4 Eurasian lineage H5Nx highly pathogenic avian influenza virus (HPAIV) has become the globally dominant clade and caused global outbreaks since 2014. The clade 2.3.4.4 viruses have evolved into eight hemagglutinin subgroups (2.3.4.4a-h). In this study, we evaluated the infectivity, pathobiology, and transmissibility of seven clade 2.3.4.4 viruses (two 2.3.4.4a, two 2.3.4.4b, one 2.3.4.4c and two 2.3.4.4e) in chickens. The two clade 2.3.4.4e viruses caused 100% mortality and transmissibility in chickens. However, clade 2.3.4.4a and c viruses showed 80-90% mortality and 67% transmissibility. Clade 2.3.4.4b viruses showed 100% mortality, but no transmission to co-housed chickens was observed based on lack of seroconversion. All the infected chickens died showing systemic infection, irrespective of subgroup. The results highlight that all the clade 2.3.4.4 HPAIVs used in this study caused high mortality in infected chickens, but the transmissibility of the viruses in chickens was variable in contrast to that of previous Eurasian-lineage H5N1 HPAIVs. Changes in the pathogenicity and transmissibility of clade 2.3.4.4 HPAIVs warrant careful monitoring of the viruses to establish effective control strategies.

논문정보

형식Research article
게재일2023년 06월 (BRIC 등록일 2023-06-27)
연구진국내(교신)+국외 연구진
분야 생명과학 > 수의학

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