강민선 (가천대학교) | 한빛사논문 > 한빛사

한빛사논문

조회474

가천대학교

CV File 202 kb

Int. J. Infect. Dis., 2023 Jun 21;S1201-9712(23)00640-9 | https://doi.org/10.1016/j.ijid.2023.06.016 Severe coronavirus disease 2019 in pediatric solid organ transplant recipients: Big data convergence study in Korea (K-COV-N cohort)

Ji-Man Kang ^a,b*, Minsun Kang ^c*, Young-Eun Kim ^d, Yoonkyung Choi ^d, Soo Jeong An ^e, Jaehyun Seong^f, Min Jin Go ^f, Kyungmin Huh ^g, Jaehun Jung ^c,h*

^aDepartment of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, South Korea
^bInstitute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea
^cArtificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea
^dDepartment of Bigdata Strategy, National Health Insurance Service, Wonju, South Korea
^eDepartment of Big Data Management, National Health Insurance Service, Wonju, South Korea
^fDivision of Clinical Research, Center for Emerging Virus Research, National Institute of Infectious Disease, National Institute of Health, Osong, South Korea
^gDivision of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
^hDepartment of Preventive Medicine, Gachon University College of Medicine, Incheon, South Korea

⁎Ji-Man Kang, Minsun Kang and Jaehun Jung contributed equally to this work.
Corresponding author: Kyungmin Huh, MD, Jaehun Jung, MD, PhD

Abstract

Objectives: The risk of severe COVID-19 in children with a solid organ transplant (SOT) is not well established. We compare the relative risk of severe COVID-19 infection between pediatric SOT and non-SOT children.

Methods: The newly constructed K-COV-N cohort (Korea Disease Control and Prevention Agency-COVID-19-National Health Insurance Service) was used. Children with COVID-19 (<18 years old) who underwent SOT between January 2008-January 2022 were included. Non-SOT children with COVID-19 were selected in a ratio of 1:4 using propensity score matching. Three definitions of severe COVID-19 were established based on their requirement of respiratory support: Severe I (requiring respiratory support above a high-flow nasal cannula or prolonged hospitalization ≥6 days), Severe II (requiring any oxygen supplement), and Severe III (requiring any oxygen supplement or prolonged hospitalization ≥6 days).

Results: Among 2,957,323 children with COVID-19, 206 pediatric SOTRs were identified and included in the analysis along with 803 matched non-SOT children. Most infections (96.6%) occurred during the Omicron period; no cases of mortality were reported. Pediatric SOTR had a 3.6-fold (95% CI=1.1-11.7, P=0.03) higher risk of Severe I, and a 4.9-fold (95% CI=1.6-15.0, P=0.006) higher risk of Severe III than non-SOT children. No cases of Severe II occurred in the non-SOT children. Although not statistically significant, no severe COVID-19 cases were reported in the vaccinated SOT group (0.0% vs 5.7%, P=0.09 in Severe III).

Conclusions: Pediatric SOTRs have a significantly higher risk of severe COVID-19 than non-SOT children. Our findings support the need for tailored strategies for these high-risk children.

논문정보

형식Research article
게재일2023년 06월 (BRIC 등록일 2023-06-26)
연구진국내 연구진
분야 의약학 > 응용의학

댓글 작성 로그인

CV 열람하기

연락처 보기