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조회541

Rice University

Cell Reports, 2023 May 24;42(6):112554 | https://doi.org/10.1016/j.celrep.2023.112554 Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes

Roy Lycke ^1,2,8, Robin Kim ^1,2,8, Pavlo Zolotavin ^1,2, Jon Montes ^2,3, Yingchu Sun ^1,2, Aron Koszeghy ⁴, Esra Altun ^2,5, Brian Noble^2,6, Rongkang Yin^1,2, Fei He ^1,2, Nelson Totah ^4,7, Chong Xie ^1,2,3, Lan Luan^1,2,3,9

¹Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA
²Rice Neuroengineering Initiative, Rice University, Houston, TX 77005, USA
³Department of Bioengineering, Rice University, Houston, TX 77005, USA
⁴Helsinki Institute of Life Science (HiLIFE), University of Helsinki, 00790 Helsinki, Finland
⁵Material Science and NanoEngineering, Rice University, Houston, TX 77005, USA
⁶Applied Physics Program, Rice University, Houston, TX 77005, USA
⁷Faculty of Pharmacy, University of Helsinki, 00790 Helsinki, Finland
⁸These authors contributed equally
⁹Lead contact

Corresponding authors: Chong Xie, Lan Luan

Abstract

Intracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to causal circuit manipulations. However, the resolution, efficacy, and chronic stability of neuromodulation are often compromised by adverse tissue responses to the indwelling electrodes. Here we engineer ultraflexible stim-nanoelectronic threads (StimNETs) and demonstrate low activation threshold, high resolution, and chronically stable ICMS in awake, behaving mouse models. In vivo two-photon imaging reveals that StimNETs remain seamlessly integrated with the nervous tissue throughout chronic stimulation periods and elicit stable, focal neuronal activation at low currents of 2 μA. Importantly, StimNETs evoke longitudinally stable behavioral responses for over 8 months at a markedly low charge injection of 0.25 nC/phase. Quantified histological analyses show that chronic ICMS by StimNETs induces no neuronal degeneration or glial scarring. These results suggest that tissue-integrated electrodes provide a path for robust, long-lasting, spatially selective neuromodulation at low currents, which lessens risk of tissue damage or exacerbation of off-target side effects.

논문정보

형식Research article
게재일2023년 05월 (BRIC 등록일 2023-06-23)
연구진국외 연구진
분야 바이오·의료융합 > 뇌인지과학

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