한빛사논문
- 조회341
Sunho Park 1 2 3, Yeon Ju Kim 4 5, Harshita Sharma 1 2 3, Dream Kim 1 2 3, Yonghyun Gwon 1 2 3, Woochan Kim 1 2 3, Sangbae Park 1 2 3, Cheol Woo Ha 6, Yun-Hoon Choung 5 *, Jangho Kim 1 2 3 *
1Department of Convergence Biosystems Engineering, Chonnam National University, Gwangju 61186, Republic of Korea.
2Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju 61186, Republic of Korea.
3Interdisciplinary Program in IT-Bio Convergence System, Chonnam National University, Gwangju 61186, Republic of Korea.
4Department of Neurology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
5Department of Otolaryngology, Ajou University School of Medicine, Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
6Advanced Joining and Additive Manufacturing R&D Department, Korea Institute of Industrial Technology, 113-58, Seohaean-ro, Siheung 15014, Republic of Korea.
*Corresponding author: correspondence to Yun-Hoon Choung or Jangho Kim
Abstract
Inner ear organoids (IEOs) are 3D structures grown in vitro, which can mimic the complex cellular structure and function of the inner ear. IEOs are potential solutions to problems related to inner ear development, disease modeling, and drug delivery. However, current approaches in generating IEOs using chemical factors have a few limitations, resulting in unpredictable outcomes. In this study, we propose the use of nanomaterial-based approaches, specifically by using graphene oxide (GO). GO’s unique properties promote cell–extracellular matrix interactions and cell–cell gap junctions, thereby enhancing hair cell formation, which is an essential part of IEO development. We also investigated the potential applications for drug testing. Our findings suggest that GO is a promising candidate for enhancing the functionality of IEOs and advancing our understanding of the problems underlying inner ear development. The use of nanomaterial-based approaches may provide a more reliable and effective method for building better IEOs in the future.
논문정보
- Research article
- 2023년 06월 (BRIC 등록일 2023-06-26)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
관련분야 논문보기
해당논문 저자보기
