한빛사논문
- 조회184
Xiaojing Liu a, Deepak Kukkar b,c, Ziai Deng a, Di Yang a, Jianlong Wang a, Ki-Hyun Kim d, Daohong Zhang a
aCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, China
bDepartment of Biotechnology, Chandigarh University, Gharuan, Mohali, 147013, Punjab, India
cUniversity Centre for Research and Development, Chandigarh University, Gharuan, Mohali, 147013, Punjab, India
dDepartment of Civil and Environmental Engineering, Hanyang University, Seongdong-gu, Wangsimni-ro, Seoul, 04763, South Korea
Corresponding authors: Ki-Hyun Kim, Daohong Zhang
Abstract
In light of severe health risks of foodborne pathogenic bacterial diseases, the potential utility of point-of-care (POC) sensors is recognized for pathogens detection. In this regard, lateral flow assay (LFA) is a promising and user-friendly option for such application among various technological approaches. This article presents a comprehensive review of "lock-and-key" recognizer-encoded LFAs with respect to their working principles and detection performance against foodborne pathogenic bacteria. For this purpose, we describe various strategies for bacteria recognition including the antibody-based antigen-antibody interactions, nucleic acid aptamer-based recognition, and phage-mediated targeting of bacterial cells. In addition, we also outline the technological challenges along with the prospects for the future development of LFA in food analysis. The LFA devices built based upon many recognition strategies are found to have great potential for rapid, convenient, and effective POC detection of pathogens in complex food matrixes. Future developments in this field should emphasize the development of high-quality bio-probes, multiplex sensors, and intelligent portable readers.
논문정보
- Review Paper
- 2023년 05월 (BRIC 등록일 2023-08-22)
- 국내(교신)+국외 연구진
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