한빛사논문
- 조회317
Yongwoo Lee 1, Alejandro Carnicer-Lombarte 2, Sanggil Han 2,3, Ben J Woodington 2, Seungjin Chai 1, Anastasios G Polyravas 2, Santiago Velasco-Bosom 2, Eun-Hee Kim 4, George G Malliaras 2, Sungjune Jung 1,5
1Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, Republic of Korea.
2Electrical Engineering Division, Department of Engineering, University of Cambridge, 9 JJ Thomson Ave, Cambridge, CB3 0FA, UK.
3Department of Nano-Bioengineering, Incheon National University, Incheon, 22012, Republic of Korea.
4Department of Pediatrics, Chungnam National University Sejong Hospital, Chungnam National University School of Medicine, 20 Bodeum 7-ro, Sejong, 30099, Republic of Korea.
5Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, 37673, Republic of Korea.
CORRESPONDING AUTHORS: George G. Malliaras, Sungjune Jung
Abstract
Neural recording systems have significantly progressed to provide an advanced understanding and treatment for neurological diseases. Flexible transistor-based active neural probes exhibit great potential in electrophysiology applications due to their intrinsic amplification capability and tissue-compliant nature. However, most current active neural probes exhibit bulky back-end connectivity since the output is current, and the development of an integrated circuit for voltage output is crucial for near-sensor signal processing at the abiotic/biotic interface. Here, we present inkjet-printed organic voltage amplifiers by monolithically integrating organic electrochemical transistors and thin-film polymer resistors on a single, highly flexible substrate for in vivo brain activity recording. Additive inkjet printing enables the seamless integration of multiple active and passive components on the somatosensory cortex, leading to significant noise reduction over the externally connected typical configuration. It also facilitates fine-tuning of the voltage amplification and frequency properties. We validate the organic voltage amplifiers as electrocorticography devices in a rat in vivo model, showing their ability to record local field potentials in an experimental model of spontaneous and epileptiform activity. Our results bring organic active neural probes to the forefront in applications where efficient sensory data processing is performed at sensor endpoints.
논문정보
- Research article
- 2023년 05월 (BRIC 등록일 2023-06-20)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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