한빛사논문
- 조회461
Ji-Won Kim,1,2,⊥ Sang Hoon Han,1,3⊥ Minhee Ku,4⊥ Jaemoon Yang,4,* and Shin-Hyun Kim1,*
1Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea;
2Present Address: Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States (J.W.K.)
3Present Address: Samsung Electronics, Yongin 17113, Republic of Korea (S.H.H.).
4Department of Radiology, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea
⊥J.-W.K., S.H.H., and M.K. contributed equally to this work.
*Corresponding Authors : Jaemoon Yang, Shin-Hyun Kim
Abstract
Chemophotothermal therapy is promising for cancer treatment with its synergistic effect. Although various photothermal agents have been formulated as drug carriers, low payload, burst release, and severe dilution usually restrict their uses. To overcome the limitations, we design smart microcapsules as a pragmatic material for chemophotothermal therapy. With a microfluidic device, water-in-oil-in-water (W/O/W) double-emulsion templates are produced to have photothermal polydopamine nanoparticles and drugs in the water core and a mixture of photocurable monomers and phase-change material (PCM) in the oil shell. The droplets are significantly shrunken by the osmotic extraction of water from the core, which enables the size reduction for the ease of injection and enrichment of polydopamine nanoparticles and drugs for enhanced photothermal performance and high payload. The microcapsules, produced by photopolymerization of monomers, release drugs when PCM in continuous nanochannels of the polymer shell is molten while retaining drugs without leakage when frozen. As the concentrated polydopamine nanoparticles provide rapid and drastic heating by near-infrared irradiation, the drug release can be switched on and off in a programmed manner by manipulating the irradiation. The smart microcapsules secure high drug payload in a spacious core, negligible initial bursting, and dilution-free high photothermal performance, potentially serving as a pragmatic therapy platform.
논문정보
- Research article
- 2023년 06월 (BRIC 등록일 2023-06-20)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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