한빛사논문
- 조회521
Jungho Ahn 1,†, Tugce Sen 2,†, Danbi Lee 3,†, Hyeonji Kim 2, Jae Yeon Lee 4, Hwa Seon Koo 5, Jae Yun Kim 7, Jisoo Kim 7, Jinah Jang 2,6,7,*, Youn-Jung Kang 1,* and Dong-Woo Cho 2,*
1Department of Biochemistry Research Institute for Basic Medical Science School of Medicine CHA University 335 Pangyo, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, South Korea
2Department of Mechanical Engineering Pohang University of Science and Technology 77 Cheongamro, Nam-gu, Gyeongsangbuk-do, Pohang 37673, South Korea
3Department of Biomedical Science School of Life Science CHA University 335 Pangyo, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, South Korea
4Department of Companion Animal Health Daegu Haany University Gyeongsan 38610, South Korea
5CHA Fertility Center Bundang 59, Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13496, South Korea
6Department of Convergence IT Engineering Pohang University of Science and Technology 77 Cheongam-ro, Nam-gu, Gyeongsangbuk-do, Pohang 37673, South Korea
7School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology 77 Cheongam-ro, Nam-gu, Gyeongsangbuk-do, Pohang 37673, South Korea
†These authors contributed equally
*Corresponding author: correspondence to Jinah Jang, Youn-Jung Kang or Dong-Woo Cho
Abstract
Tissue-specific decellularized extracellular matrix recapitulates the complexity of natural ECMs, creating an organ-specific microenvironment based on its intrinsic characteristics. Here, hydrogels containing uterus-derived decellularized extracellular matrix (UdECMs) from the endometrium-specific layer or the entire uterus are developed. UdECMs serve as effective organ-specific biomaterials, displaying that intrauterine UdECM administration induces endometrial regeneration and fertility enhancement. Moreover, UdECM administration alters the profile of natural killer cell subpopulations to exhibit more mature and less cytotoxic features, providing a favorable uterine environment for successful implantation and decidualization. Interestingly, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 as key regulatory factors that contribute to UdECM-mediated endometrial regeneration are discovered. Furthermore, ex vivo culture of human uterine tissues reveals that UdECMs of different origins exhibit distinct therapeutic effects based on the endometrial conditions of patients, suggesting their uses as a therapeutic intervention providing personalized regenerative medicine for infertile patients with a poor uterine environment.
논문정보
- Research article
- 2023년 06월 (BRIC 등록일 2023-06-20)
- 국내 연구진
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