한빛사논문
- 조회655
Shinwoo Kang 1†, Sa-Ik Hong 1†, Seungwoo Kang 1,2†, Minryung Song 3, Minsu Abel Yang 3,4, Hesham Essa 1, Matthew Baker 1, Jeyeon Lee 5, Robert A. Bruce 1, Sang Wan Lee 3,6,7, Doo-Sup Choi 1,8,9*
1Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
2Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
3Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
4Program of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
5Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
6Department of Brain and Cognitive Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
7Kim Jaechul Graduate School of AI, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
8Departmentof Psychiatry and Psychology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
9Neuroscience Program, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
*Corresponding author: correspondence to Doo-Sup Choi
†These authors contributed equally to this work.
Abstract
An imbalance in goal-directed and habitual behavioral control is a hallmark of decision-making–related disorders, including addiction. Although external globus pallidus (GPe) is critical for action selection, which harbors enriched astrocytes, the role of GPe astrocytes involved in action-selection strategies remained unknown. Using in vivo calcium signaling with fiber photometry, we found substantially attenuated GPe astrocytic activity during habitual learning compared to goal-directed learning. The support vector machine analysis predicted the behavioral outcomes. Chemogenetic activation of the astrocytes or inhibition of GPe pan-neuronal activities facilitates the transition from habit to goal-directed reward-seeking behavior. Next, we found increased astrocyte-specific GABA (γ-aminobutyric acid) transporter type 3 (GAT3) messenger RNA expression during habit learning. Notably, the pharmacological inhibition of GAT3 occluded astrocyte activation–induced transition from habitual to goal-directed behavior. On the other hand, attentional stimuli shifted the habit to goal-directed behaviors. Our findings suggest that the GPe astrocytes regulate the action selection strategy and behavioral flexibility.
논문정보
- Research article
- 2023년 06월 (BRIC 등록일 2023-06-20)
- 국내+국외 연구진
- 의약학 > 신경의학
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