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서울시보건환경연구원

J. Clin. Virol., 2023 Jul;164:105497 | https://doi.org/10.1016/j.jcv.2023.105497 Genotypic shift in rotavirus associated with neonatal outbreaks in Seoul, Korea

Jin Seok Kim ^a, Hyo-Won Jeong ^a, Sook Hyun Park ^a, Jin-ah Kim ^a, Young Hee Jin ^a, Hyun Soo Kim ^b, Soyoung Jung ^a, Jae In Lee ^a, Jib-Ho Lee ^a

^aEmerging Infectious Diseases Team, Seoul Metropolitan Government Research Institute of Public Health and Environment, Gyeonggi-do, Republic of Korea
^bDepartment of Laboratory Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Gyeonggi-do, Republic of Korea

Corresponding author : Jin Seok Kim

Abstract

Background: Rotavirus group A (RVA) is a causative agent of acute gastroenteritis among young children worldwide, despite the global expansion of rotavirus vaccination. In Korea, although the prevalence of RVA has been reduced among young children owing to vaccination, nosocomial infections still occur among neonates.

Objectives: The aim of this study was to investigate the molecular epidemiology of RVA strains associated with several neonatal outbreaks in Seoul from 2017 to 2020.

Study design: Clinical and environmental samples were collected and screened for the presence of RVA using ELISA and PCR targeting VP6, respectively. RVA-positive strains were genotyped via RT-PCR and subsequent sequencing of VP4 and VP7 and were phylogenetically compared with RVA strains from other countries.

Results: During 2017-2020, a total of 15 RVA outbreaks occurred at neonatal facilities (six in hospital neonatal wards and nine in postpartum care centers) in Seoul, and only two RVA genotypes were detected: G4P[6] and G8P[6]. G8P[6] emerged in Seoul November 2018 and immediately became the predominant genotype among neonates, at least up to 2020. Phylogenetic analysis revealed that the G8P[6] genotype in this study was closely related to G8P[6] strains first identified in Korea in 2017, but differed from G8P[6] strains detected in Africa.

Conclusions: A novel G8P[6] genotype of RVA strains has emerged and caused outbreaks among neonates in Seoul. Continued surveillance for circulating RVA genotypes is imperative to monitor genotype changes and their potential risks to public health.

논문정보

형식Research article
게재일2023년 06월 (BRIC 등록일 2023-06-15)
연구진국내 연구진
분야 생명과학 > 미생물학

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