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조회477

이현Hyun Lee

가톨릭대학교

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Adv. Sci., 2023 Jun;10(17):e2300816 | https://doi.org/10.1002/advs.202300816 3D-Printed Functional Hydrogel by DNA-Induced Biomineralization for Accelerated Diabetic Wound Healing

Nahyun Kim^1,2, Hyun Lee ^1,2, Ginam Han ^1,2, Minho Kang ^1,2, Sinwoo Park^1,2, Dong Eung Kim ³, Minyoung Lee ^4,5, Moon-Jo Kim ³, Yuhyun Na ^1,2, SeKwon Oh ³, Seo-Jun Bang^1,2, Tae-Sik Jang ⁶, Hyoun-Ee Kim⁷, Jungwon Park^4,5, Su Ryon Shin ⁸, Hyun-Do Jung^1,2

¹Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.
²Department of Biotechnology, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.
³Research Institute of Advanced Manufacturing & Materials Technology, Korea Institute of Industrial Technology, Incheon, 21999, Republic of Korea.
⁴School of Chemical and Biological Engineering, and Institute of Chemical Processes (ICP), Seoul National University, Seoul, 08826, Republic of Korea.
⁵Center for Nanoparticle Research, Institute of Basic Science (IBS), Seoul, 08826, Republic of Korea.
⁶Department of Materials Science and Engineering, Chosun University, Gwangju, 61452, Republic of Korea.
⁷Department of Materials Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
⁸Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA, 02139, USA.

N.K. and H.L. contributed equally to this work.
CORRESPONDING AUTHOR : Hyun-Do Jung

Abstract

Chronic wounds in diabetic patients are challenging because their prolonged inflammation makes healing difficult, thus burdening patients, society, and health care systems. Customized dressing materials are needed to effectively treat such wounds that vary in shape and depth. The continuous development of 3D-printing technology along with artificial intelligence has increased the precision, versatility, and compatibility of various materials, thus providing the considerable potential to meet the abovementioned needs. Herein, functional 3D-printing inks comprising DNA from salmon sperm and DNA-induced biosilica inspired by marine sponges, are developed for the machine learning-based 3D-printing of wound dressings. The DNA and biomineralized silica are incorporated into hydrogel inks in a fast, facile manner. The 3D-printed wound dressing thus generates provided appropriate porosity, characterized by effective exudate and blood absorption at wound sites, and mechanical tunability indicated by good shape fidelity and printability during optimized 3D printing. Moreover, the DNA and biomineralized silica act as nanotherapeutics, enhancing the biological activity of the dressings in terms of reactive oxygen species scavenging, angiogenesis, and anti-inflammation activity, thereby accelerating acute and diabetic wound healing. These bioinspired 3D-printed hydrogels produce using a DNA-induced biomineralization strategy are an excellent functional platform for clinical applications in acute and chronic wound repair.

논문정보

형식Research article
게재일2023년 06월 (BRIC 등록일 2023-06-16)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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