한빛사논문
- 조회327
Arun Kumar Rajendran1†, Deepthi Sankar2†, Sivashanmugam Amirthalingam1,3†, Hwan D. Kim4,5, Jayakumar Rangasamy2* and Nathaniel S. Hwang1,3,6,7*
1School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
2Polymeric Biomaterials Lab, School of Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi 682041, India.
3Institute of Engineering Research, Seoul National University, Seoul 08826, Republic of Korea.
4Department of Polymer Science and Engineering, Korea National University of Transportation, Chungju 27469, Republic of Korea.
5Department of Biomedical Engineering, Korea National University of Transportation, Chungju 27469, Republic of Korea.
6Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea.
7Bio-MAX/N-Bio Institute, Institute of Bio-Engineering, Seoul National University, Seoul 08826, Republic of Korea.
†Arun Kumar Rajendran, Deepthi Sankar and Sivashanmugam Amirthalingam contributed equally to this work.
*Correspondence: Jayakumar Rangasamy, Nathaniel S. Hwang
Abstract
Sensing the mechanical properties of the substrates or the matrix by the cells and the tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels and the outcomes are beginning to get unraveled more recently. There have been various instances where researchers have established the underlying connection between the cellular mechanosignalling pathways and cellular physiology, cellular differentiation, and also tissue pathology. It has been now accepted that mechanosignalling, alone or in combination with classical pathways, could play a significant role in fate determination, development, and organization of cells and tissues. Furthermore, as mechanobiology is gaining traction, so do the various techniques to ponder and gain insights into the still unraveled pathways. This review would briefly discuss some of the interesting works wherein it has been shown that specific alteration of the mechanical properties of the substrates would lead to fate determination of stem cells into various differentiated cells such as osteoblasts, adipocytes, tenocytes, cardiomyocytes, and neurons, and how these properties are being utilized for the development of organoids. This review would also cover various techniques that have been developed and employed to explore the effects of mechanosignalling, including imaging of mechanosensing proteins, atomic force microscopy (AFM), quartz crystal microbalance with dissipation measurements (QCMD), traction force microscopy (TFM), microdevice arrays, Spatio-temporal image analysis, optical tweezer force measurements, mechanoscanning ion conductance microscopy (mSICM), acoustofluidic interferometric device (AID) and so forth. This review would provide insights to the researchers who work on exploiting various mechanical properties of substrates to control the cellular and tissue functions for tissue engineering and regenerative applications, and also will shed light on the advancements of various techniques that could be utilized to unravel the unknown in the field of cellular mechanobiology.
논문정보
- Review Paper
- 2023년 06월 (BRIC 등록일 2023-06-15)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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