한빛사논문
- 조회351
Sumin Jeong 1,2, Wookjin Shin 1, Mansoo Park 1,3, Jung-Uk Lee 1, Yongjun Lim 1,2, Kunwoo Noh 1,3, Jae-Hyun Lee 1,3, Young-Wook Jun 1,3,4,5,6, Minsuk Kwak 1,3, Jinwoo Cheon 1,2,3
1Center for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea.
2Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea.
3Department of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul 03722, Republic of Korea.
4Department of Otolaryngology, University of California, San Francisco, California 94158, USA.
5Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA.
6Helen Diller Family Cancer Comprehensive Center (HDFCCC), University of California, San Francisco, California 94158, USA.
S.J. and W.S. contributed equally to this work.
Corresponding Authors : Young-wook Jun, Minsuk Kwak, Jinwoo Cheon
Abstract
As a new enabling nanotechnology tool for wireless, target-specific, and long-distance stimulation of mechanoreceptors in vivo, here we present a hydrogel magnetomechanical actuator (h-MMA) nanoparticle. To allow both deep-tissue penetration of input signals and efficient force generation, h-MMA integrates a two-step transduction mechanism that converts magnetic anisotropic energy to thermal energy within its magnetic core (i.e., Zn0.4Fe2.6O4 nanoparticle cluster) and then to mechanical energy to induce the surrounding polymer (i.e., pNiPMAm) shell contraction, finally delivering forces to activate targeted mechanoreceptors. We show that h-MMAs enable on-demand modulation of Notch signaling in both fluorescence reporter cell lines and a xenograft mouse model, demonstrating its utility as a powerful in vivo perturbation approach for mechanobiology interrogation in a minimally invasive and untethered manner.
논문정보
- Research article
- 2023년 05월 (BRIC 등록일 2023-06-15)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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