한빛사논문
- 조회426
Angelo M. Jamerlan 1, Kyu Hwan Shim 1, Young Chul Youn 2, Charlotte Teunissen 3, Seong Soo A An 1, Philip Scheltens 4, SangYun Kim 5
1Department of Bionano Technology, Bionano Research Institute, Gachon University, Gyeonggi-do, Republic of Korea.
2Department of Neurology, Chung-Ang University Hospital, Seoul, Republic of Korea.
3Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
4Department of Neurology & Alzheimer Center, Amsterdam University Medical Center, Amsterdam, The Netherlands.
5Department of Neurology, Seoul National University Bundang Hospital & Seoul National University College of Medicine, Gyeonggi-do, Republic of Korea.
Angelo M. Jamerlan and Kyu Hwan Shim are contributed equally.
CORRESPONDING AUTHORS : Seong Soo A. An, SangYun Kim
Abstract
Introduction: Semantic dementia (SD) is a progressive neurodegenerative disease associated with impaired vocabulary that progresses to memory impairment. Post-mortem immunohistochemical analysis is the current reliable method of differentiating TDP-43 deposits in cortical tissue; no means of antemortem diagnosis exists in biofluids, let alone in plasma.
Methods: Here the multimer detection system (MDS) was used to quantify the oligomeric TDP-43 (o-TDP-43) concentrations in plasma of Korean SD patients (n = 16, 6 male, 10 female, ages 59-87). The o-TDP-43 concentrations were compared with the total TDP-43 (t-TDP-43) concentrations quantified through conventional enzyme-linked immunosorbent assay (ELISA).
Results and discussion: Only MDS showed a significant increase in o-TDP-43 concentrations in the plasma of patients with SD compared to other neurodegenerative disorders and normal controls (p < 0.05). Based on these results, o-TDP-43 concentrations through the application of MDS may be a useful plasma biomarker in SD-FTD (frontotemporal dementia) diagnosis.
논문정보
- Research article
- 2023년 05월 (BRIC 등록일 2023-06-15)
- 국내(교신)+국외 연구진
- 의약학 > 신경의학
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