Neha Kaushik (수원대학교) | 한빛사논문 > 한빛사

한빛사논문

조회227

수원대학교

Biochim. Biophys. Acta-Rev. Cancer, 2023 May 15;1878(4):188915 | https://doi.org/10.1016/j.bbcan.2023.188915 Functional impact of non-coding RNAs in high-grade breast carcinoma: Moving from resistance to clinical applications: A comprehensive review

Apurva Jaiswal ^a,1, Neha Kaushik ^b,1*, Eun Ha Choi ^a*, Nagendra Kumar Kaushik ^a*

^aPlasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Republic of Korea
^bDepartment of Biotechnology, College of Engineering, The University of Suwon, Suwon 18323, Republic of Korea

¹These authors contributed equally.
*Corresponding authors : Neha Kaushik, Eun Ha Choi, Nagendra Kumar Kaushik

Abstract

Despite the recent advances in cancer therapy, triple-negative breast cancers (TNBCs) are the most relapsing cancer sub-type. It is partly due to their propensity to develop resistance against the available therapies. An intricate network of regulatory molecules in cellular mechanisms leads to the development of resistance in tumors. Non-coding RNAs (ncRNAs) have gained widespread attention as critical regulators of cancer hallmarks. Existing research suggests that aberrant expression of ncRNAs modulates the oncogenic or tumor suppressive signaling. This can mitigate the responsiveness of efficacious anti-tumor interventions. This review presents a systematic overview of biogenesis and down streaming molecular mechanism of the subgroups of ncRNAs. Furthermore, it explains ncRNA-based strategies and challenges to target the chemo-, radio-, and immunoresistance in TNBCs from a clinical standpoint.

논문정보

형식Review Paper
게재일2023년 05월 (BRIC 등록일 2023-06-14)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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