한빛사논문
- 조회521
Hye Jin Jang1,3, Dong Yoon Lee1,3, Gjustina Loloci1, Jihyeon Jeong2 and Won-il Choi1*
1Department of Internal Medicine, Myongji Hospital, Hanyang University, Gyeonggi-do, Republic of Korea
2Department of Statistics, Kyungpook National University, Daegu, Republic of Korea
3These authors contributed equally to this work.
*Corresponding author: Won-Il Choi
Abstract
Background: We aimed to study whether statin use is associated with lowering the development of interstitial lung disease (ILD) or idiopathic pulmonary fibrosis (IPF).
Methods: The study population was the National Health Insurance Service-Health Screening Cohort (NHIS-HEALS). ILD and IPF cases were identified using the diagnosis codes (J84.1 for ILD and J84.1A for special code for IPF) based on the International Classification of Diseases, 10th revision codes. The study participants were followed up from January 1, 2004 to December 31, 2015. Statins use was defined by the cumulative defined daily dose per 2-year interval and categorized into never-use, less than 182.5, 182.5 to 365.0, 365.0 to 547.5, and 547.5 or more. A Cox model was used to fit a model with a time-dependent variable of statin use.
Results: Incidence rates for ILD with and without statin use were 20.0 and 44.8/100 000 person-year, respectively and those for IPF were 15.6 and 19.3/100 000 person-year, respectively. The use of statins was independently associated with a lower incidence of ILD and IPF in a dose-response fashion (p's for trend<0.001). ILD showed adjusted hazard ratios (aHRs) 1.02 (95% confidence interval (CI) 0.87-1.20), 0.60 (0.47-0.77), 0.27 (0.16-0.45) and 0.24 (0.13-0.42) according to the increasing category of statin use compared to the never-use. IPF showed aHRs 1.29 (1.07-1.57), 0.74 (0.57-0.96), 0.40 (0.25-0.64) and 0.21 (0.11-0.41), respectively.
Interpretation: A population-based cohort analysis found that statin use is independently associated with a decreased risk of ILD and IPF in a dose-response manner.
논문정보
- Research article
- 2023년 05월 (BRIC 등록일 2023-06-14)
- 국내 연구진
- 의약학 > 응용의학
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