한빛사논문
- 조회432
Lim, Jihye MD, PhD1; Kim, Ye-Jee PhD2; Kim, Seonok MSc2; Choi, Jonggi MD, PhD3,a
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
2Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
3Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
aCorrespondence: Jonggi Choi, MD, PhD
Abstract
Objectives: Few large-scale studies have been published regarding the association between autoimmune hepatitis (AIH) and risk of osteoporotic fracture. This study aimed to determine the risk of developing an osteoporotic fracture in patients with AIH.
Methods: We used claims data from the Korean National Health Insurance Service (NHIS) between 2007 and 2020. Patients with AIH (n = 7,062) were matched with controls (n = 28,122) based on age, sex, and duration of follow-up using a ratio of 1:4. Osteoporotic fractures included fractures of the vertebrae, hip, distal radius, and proximal humerus. The incidence rate (IR) and incidence rate ratio (IRR) of osteoporotic fracture were compared between the two groups, and their associated factors were evaluated.
Results: During a median follow-up period of 5.4 years, 712 osteoporotic fractures occurred in patients with AIH with an IR of 17.5 per 1,000 person-years. Patients with AIH had a significantly higher risk of osteoporotic fractures than matched controls, with an IRR of 1.24 (95% confidence intervals, 1.10-1.39, P<0.01) in the multivariable analysis. Female sex, older age, history of stroke, presence of cirrhosis, and use of glucocorticoids were associated with an increased risk of osteoporotic fractures. In the two-year landmark analysis, longer duration of glucocorticoid exposure was associated with an incremental increased risk of osteoporotic fracture.
Conclusions: Patients with AIH had an increased risk of osteoporotic fracture compared to controls. Presence of cirrhosis and long-term use of glucocorticoids further adversely affected osteoporotic fracture in patients with AIH.
논문정보
- Research article
- 2023년 06월 (BRIC 등록일 2023-06-13)
- 국내 연구진
- 의약학 > 응용의학
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