한빛사논문
- 조회573
Su-Man Kim 1 2 18, Shinhye Park 1 3 18, Seung-Ho Hwang 1, Eun-Young Lee 1, Jong-Hwan Kim 4, Ga Seul Lee 5 6, Giljae Lee 7, Dong-Ho Chang 1, Jae-Geun Lee 1, Jungwon Hwang 1, Youngjin Lee 1, Minsoo Kyung 8, Eun-Kyoung Kim 8, Jae-Hoon Kim 9 19, Tae-Hwan Kim 1 10, Jeong Hee Moon 5, Byoung-Chan Kim 1 11, GwangPyo Ko 7 12 13 14, Seon-Young Kim 4 15, Ji-Hwan Ryu 16, Jeong-Soo Lee 1 15, Chul-Ho Lee 9 15, Jeong-Yoon Kim 3, Sunghoon Kim 17, Won-Jae Lee 8, Myung Hee Kim 1 20 *
1Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea
2Department of Biology Education, Chonnam National University, Gwangju 61186, Korea
3Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon 34134, Korea
4Korean Bioinformation Center, KRIBB, Daejeon 34141, Korea
5Core Research Facility & Analysis Center, KRIBB, Daejeon 34141, Korea
6College of Pharmacy, Chungbuk National University, Cheongju 28160, Chungbuk, Korea
7Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea
8National Creative Research Initiative Center for Hologenomics and School of Biological Sciences, Seoul National University, Seoul 08826, Korea
9Laboratory Animal Resource Center, KRIBB, Daejeon 34141, Korea
10College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea
11HealthBiome, Inc., Bioventure Center, Daejeon 34141, Korea
12Center for Human and Environmental Microbiome, Institute of Health and Environment, Seoul National University, Seoul 08826, Korea
13KoBioLabs, Inc., Seoul 08826, Korea
14Bio-MAX/N-Bio, Seoul National University, Seoul 08826, Korea
15Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Korea
16Severance Biomedical Science Institute and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea
17Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy and College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon 21983, Republic of Korea
18These authors contributed equally
19Present address: Livestock Products Analysis Division, Division of Animal Health, Daejeon Metropolitan City Institute of Health and Environment, Daejeon 34146, Korea
20Lead contact
*Corresponding author: correspondence to Myung Hee Kim
Abstract
Commensal bacteria are critically involved in the establishment of tolerance against inflammatory challenges, the molecular mechanisms of which are just being uncovered. All kingdoms of life produce aminoacyl-tRNA synthetases (ARSs). Thus far, the non-translational roles of ARSs have largely been reported in eukaryotes. Here, we report that the threonyl-tRNA synthetase (AmTARS) of the gut-associated bacterium Akkermansia muciniphila is secreted and functions to monitor and modulate immune homeostasis. Secreted AmTARS triggers M2 macrophage polarization and orchestrates the production of anti-inflammatory IL-10 via its unique, evolutionary-acquired regions, which mediates specific interactions with TLR2. This interaction activates the MAPK and PI3K/AKT signaling pathways, which converge on CREB, leading to an efficient production of IL-10 and suppression of the central inflammatory mediator NF-κB. AmTARS restores IL-10-positive macrophages, increases IL-10 levels in the serum, and attenuates the pathological effects in colitis mice. Thus, commensal tRNA synthetases can act as intrinsic mediators that maintain homeostasis.
논문정보
- Research article
- 2023년 06월 (BRIC 등록일 2023-06-12)
- 국내 연구진
- 생명과학 > 생화학
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