한빛사논문
- 조회545
Jin Ju Kim a,1, Hoon Je Seong a,b,1, Timothy A. Johnson c, Chang-Jun Cha a, Woo Jun Sul a, Jong-Chan Chae d
aDepartment of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea
bKorean Medicine Data Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea
cDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, United States
dDivision of Biotechnology, Jeonbuk National University, Iksan 54596, Republic of Korea
1These authors contributed equally: Jin Ju Kim and Hoon Je Seong
Corresponding authors: Woo Jun Sul, Jong-Chan Chae
Abstract
Concerns about antibiotic resistance genes (ARGs) released from wastewaters of livestock or fish farming into the natural environment are increasing, but studies on unculturable bacteria related to the dissemination of antibiotic resistance are limited. Here, we reconstructed 1100 metagenome-assembled genomes (MAGs) to assess the impact of microbial antibiotic resistome and mobilome in wastewaters discharged to Korean rivers. Our results indicate that ARGs harbored in the MAGs were disseminated from wastewater effluents into downstream rivers. Moreover, it was found that ARGs are more commonly co-localized with mobile genetic elements (MGEs) in agricultural wastewater than in river water. Among the effluent-derived phyla, uncultured members of the superphylum Patescibacteria possessed a high number of MGEs, along with co-localized ARGs. Our findings suggest that members of the Patesibacteria are a potential vector for propagating ARGs into the environmental community. Therefore, we propose that the dissemination of ARGs by uncultured bacteria should be further investigated in multiple environments.
논문정보
- Research article
- 2023년 06월 (BRIC 등록일 2023-06-09)
- 국내(교신)+국외 연구진
- 생명과학 > 미생물학
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