한빛사논문
- 조회370
연세대학교
Kim, Hyun-Chang MD, PhDa; Park, Jinyoung MDb; Oh, Jinyoung MD, PhDe; Kim, Minjae MDc; Park, Eun Jung MD, PhDd,; Baik, Seung Hyuk MD, PhDd; Song, Young MD, PhDa
aDepartment of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute
bDepartment of Rehabilitation, Gangnam Severance Hospital
cDepartment of Anesthesiology and Pain Medicine
dDivision of Colon and Rectal Surgery, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul
eDepartment of Anesthesiology and Pain Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
Y.S. and E.J.P. contributed equally to this article.
*Corresponding authors: Y. Song, E.J. Park
Abstract
Background: To evaluate the analgesic efficacy of a four-quadrant transversus abdominis plane (4QTAP) block and a combination of 4QTAP block with needle electrical twitch and intramuscular electrical stimulation (NETOIMS) in patients undergoing cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC).
Materials and methods: Eighty-one patients who underwent CRS followed by HIPEC were included in this study. Patients were randomly assigned to one of three groups: group 1 (intravenous patient-controlled analgesia, control group), group 2 (preoperative 4QTAP block), and group 3 (preoperative 4QTAP block and postoperative NETOIMS). The primary study endpoint was the pain score assessed by the visual analog scale (VAS: 0, no pain; 10, worst imaginable pain) on postoperative day (POD) 1.
Results: The VAS pain score on POD 1 was significantly lower in group 2 than in group 1 (6.0±1.7 and 7.6±1.9, P =0.004), whereas that in group 3 was significantly lower than that in groups 1 and 2 ( P <0.001 and P =0.004, respectively). Opioid consumption and nausea and vomiting incidence during POD 7 were significantly lower in group 3 than in groups 1 and 2. Gait speed and peak cough flow on POD 4 and 7, as well as the quality of recovery (QoR)-40 score on POD 4, were significantly higher in group 3 than in groups 1 and 2.
Conclusions: The combination of a 4QTAP block with NETOIMS provided more effective analgesia than a 4QTAP block alone after CRS, followed by HIPEC, and enhanced functional restoration and quality of recovery.
논문정보
- Research article
- 2023년 05월 (BRIC 등록일 2023-06-12)
- 국내 연구진
- 의약학 > 응용의학
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