한빛사논문
- 조회439
Ji Won Han 1,2, Hee Won Yang 3, Jong Bin Bae 1,2, Dae Jong Oh 4, Dong Gyu Moon 1, Eunji Lim 5, Jin Shin 1, Bong Jo Kim 6, Dong Woo Lee 7, Jeong Lan Kim 8, Jin Hyeong Jhoo 9, Joon Hyuk Park 10, Jung Jae Lee 11, Kyung Phil Kwak 12, Seok Bum Lee 11, Seok Woo Moon 13, Seung-Ho Ryu 14, Shin Gyeom Kim 15, Ki Woong Kim 1,2,16
1Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.
2Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.
3Department of Psychiatry, Chungnam National University Hospital, Daejeon, South Korea.
4Workplace Mental Health Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
5Department of Neuropsychiatry, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.
6Department of Psychiatry, Gyeongsang National University, School of Medicine, Jinju, South Korea.
7Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, South Korea.
8Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, South Korea.
9Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, South Korea.
10Department of Neuropsychiatry, Jeju National University Hospital, Jeju, South Korea.
11Department of Psychiatry, Dankook University Hospital, Cheonan, South Korea.
12Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, South Korea.
13Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Chungju Hospital, Chungju, South Korea.
14Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Medical Center, Seoul, South Korea.
15Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea.
16Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, South Korea.
Corresponding Author: Ki Woong Kim, MD, PhD
Abstract
Importance: Although couples may share many risk factors for depressive disorders in their lifetime, whether these factors mediate the shared risk of depressive disorders has rarely been investigated.
Objectives: To identify the shared risk factors for depressive disorder in couples and investigate their mediating roles in the shared risk of depressive disorders among older adult couples.
Design, setting, and participants: This nationwide, multicenter, community-based cohort study assessed 956 older adults from the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) and a cohort of their spouses (KLOSCAD-S) between January 1, 2019, to February 28, 2021.
Exposures: Depressive disorders of the KLOSCAD participants.
Main outcomes and measures: The mediating roles of shared factors in couples on the association between one spouse's depressive disorder and the other's risk of depressive disorders was examined using structural equation modeling.
Results: A total of 956 KLOSCAD participants (385 women [40.3%] and 571 men [59.7%]; mean [SD] age, 75.1 [5.0] years) and their spouses (571 women [59.7%] and 385 men [40.3%]; mean [SD] age, 73.9 [6.1] years) were included. The depressive disorders of the KLOSCAD participants were associated with an almost 4-fold higher risk of depressive disorders in their spouses in the KLOSCAD-S cohort (odds ratio, 3.89; 95% CI, 2.06-7.19; P < .001). Social-emotional support mediated the association between depressive disorders in the KLOSCAD participants and their spouses' risk of depressive disorders by itself (β = 0.012; 95% CI, 0.001-0.024; P = .04; mediation proportion [MP] = 6.1%) and through chronic illness burden (β = 0.003; 95% CI, 0.000-0.006; P = .04; MP = 1.5%). Chronic medical illness burden (β = 0.025; 95% CI, 0.001-0.050; P = .04; MP = 12.6%) and presence of a cognitive disorder (β = 0.027; 95% CI, 0.003-0.051; P = .03; MP = 13.6%) mediated the association.
Conclusions and relevance: The risk factors shared by older adult couples may mediate approximately one-third of the spousal risk of depressive disorders. Identification of and intervention in the shared risk factors of depression among older adult couples may reduce the risk of depressive disorders in the spouses of older adults with depression.
논문정보
- Research article
- 2023년 04월 (BRIC 등록일 2023-06-12)
- 국내 연구진
- 의약학 > 응용의학
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