한빛사논문
- 조회357
Masoud Rahmati 1, Raphael Udeh 2, Dong Keon Yon 3,4, Seung Won Lee 5, Xenia Dolja-Gore 6, Mark McEVoy 7, Tony Kenna 8, Louis Jacob 9,10,11, Guillermo F López Sánchez 12, Ai Koyanagi 9,10,13, Jae Il Shin 14, Lee Smith 15
1Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
2School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia.
3Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
4Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
5Department of Precision Medicine, Sungkyunkwan University College of Medicine, Suwon, Republic of Korea.
6School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
7La Trobe Rural Health School, College of Science, Health and Engineering, La Trobe University, Bendigo, Victoria, Australia.
8Centre for Immunology & Infection Control, Queensland University of Technology, Brisbane, Queensland, Australia.
9Research and Development Unit, Parc Sanitari Sant Joan de Déu, Barcelona, Spain.
10Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), ISCIII, Madrid, Spain.
11Department of Physical Medicine and Rehabilitation, Lariboisière-Fernand Widal Hospital, AP-HP, Université Paris Cité, Paris, France.
12Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain.
13Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
14Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea.
15Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK.
Masoud Rahmati, Raphael Udeh, Dong Keon Yon, and Seung Won Lee contributed equally to this study.
CORRESPONDING AUTHORS : Masoud Rahmati, Raphael Udeh, Ai Koyanagi, Jae Il Shin
Abstract
Long-term sequelae conditions of COVID-19 at least 2-year following SARS-CoV-2 infection are unclear and little is known about their prevalence, longitudinal trajectory, and potential risk factors. Therefore, we conducted a comprehensive meta-analysis of survivors' health-related consequences and sequelae at 2-year following SARS-CoV-2 infection. PubMed/MEDLINE, CENTRAL, and EMBASE were systematically searched up to February 10, 2023. A systematic review and meta-analysis were performed to calculate the pooled effect size, expressed as event rate (ER) with corresponding 95% confidence interval (CI) of each outcome. Twelve studies involving 1 289 044 participants from 11 countries were included. A total of 41.7% of COVID-19 survivors experienced at least one unresolved symptom and 14.1% were unable to return to work at 2-year after SARS-CoV-2 infection. The most frequent symptoms and investigated findings at 2-year after SARS-CoV-2 infection were fatigue (27.4%; 95% CI 17%-40.9%), sleep difficulties (25.1%; 95% CI 22.4%-27.9%), impaired diffusion capacity for carbon monoxide (24.6%; 95% CI 10.8%-46.9%), hair loss (10.2%; 95% CI 7.3%-14.2%), and dyspnea (10.1%; 95% CI 4.3%-21.9%). Individuals with severe infection suffered more from anxiety (OR = 1.69, 95% CI 1.17-2.44) and had more impairments in forced vital capacity (OR = 9.70, 95% CI 1.94-48.41), total lung capacity (OR = 3.51, 95% CI 1.77-6.99), and residual volume (OR = 3.35, 95% CI 1.85-6.07) after recovery. Existing evidence suggest that participants with a higher risk of long-term sequelae were older, mostly female, had pre-existing medical comorbidities, with more severe status, underwent corticosteroid therapy, and higher inflammation at acute infection. Our findings suggest that 2-year after recovery from SARS-CoV-2 infection, 41.7% of survivors still suffer from either neurological, physical, and psychological sequela. These findings indicate that there is an urgent need to preclude persistent or emerging long-term sequelae and provide intervention strategies to reduce the risk of long COVID.
논문정보
- Research article
- 2023년 06월 (BRIC 등록일 2023-06-09)
- 국내(교신)+국외 연구진
- 의약학 > 인체시스템의학
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
