상위피인용논문
- 조회385
Vinit Raj 1, Jintae Lee 1
1School of Chemical Engineering, Yeungnam University, Gyeongsan-si, South Korea.
*Correspondence: Jintae Lee
Abstract
2H/4H-chromene (2H/4H-ch) is an important class of heterocyclic compounds with versatile biological profiles, a simple structure, and mild adverse effects. Researchers discovered several routes for the synthesis of a variety of 2H/4H-ch analogs that exhibited unusual activities by multiple mechanisms. The direct assessment of activities with the parent 2H/4H-ch derivative enables an orderly analysis of the structure-activity relationship (SAR) among the series. Additionally, 2H/4H-ch have numerous exciting biological activities, such as anticancer, anticonvulsant, antimicrobial, anticholinesterase, antituberculosis, and antidiabetic activities. This review is consequently an endeavor to highlight the diverse synthetic strategies, synthetic mechanism, various biological profiles, and SARs regarding the bioactive heterocycle, 2H/4H-ch. The presented scaffold work compiled in this article will be helpful to the scientific community for designing and developing potent leads of 2H/4H-ch analogs for their promising biological activities.
논문정보
- Review Paper
- 2020년 08월 (BRIC 등록일 2023-06-08)
- 국내 연구진
- 생명과학 > 미생물학
- 60회 이상 인용된 논문
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