한빛사논문
- 조회397
POSTECH
Asila Osman a,b, Enhui Lin c, Dong Soo Hwang a,c,d
aDepartment of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, South Korea
bDepartment of Chemical Engineering, University of Khartoum, Khartoum 11115, Sudan
cDivision of Environmental Science and Engineering, Pohang University of Science and Technology, Pohang 37673, South Korea
dInstitute for Convergence Research and Education in Advanced Technology, Yonsei University International Campus I-CREATE, Incheon 21983, South Korea
Corresponding author : Dong Soo Hwang
Abstract
The stickiest natural polysaccharide, levan, plays a role in metalloproteinase activation, which is an important step involved in the healing of injured tissue. However, levan is easily diluted, washed away, and loses adhesion in wet environments, which limits its biomedical applications. Herein, we demonstrate a strategy for fabricating a levan-based adhesive hydrogel for hemostatic and wound healing applications by conjugating catechol to levan. Prepared hydrogels exhibit significantly improved water solubilities, and adhesion strengths to hydrated porcine skin of up to 42.17 ± 0.24 kPa which is more than three-times that of fibrin glue adhesive. The hydrogels also promote rapid blood clotting and significantly faster healing of rat-skin incisions compared to nontreated samples. In addition, levan-catechol exhibited an immune response close to that of the negative control, which is ascribable to its significantly lower endotoxin level compared to native levan. Overall, levan-catechol hydrogels are promising materials for hemostatic and wound healing applications.
논문정보
- Research article
- 2023년 01월 (BRIC 등록일 2023-06-02)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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