한빛사논문
- 조회509
Kyung Ah Han1,2 and Jaewon Ko1,2
1Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, Korea.
2Center for Synapse Diversity and Specificity, DGIST, Daegu 42988, Korea.
Corresponding author : Correspondence to Jaewon Ko.
Abstract
The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.
논문정보
- Review Paper
- 2023년 06월 (BRIC 등록일 2023-06-02)
- 국내 연구진
- 생명과학 > 신경생물학
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