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Sci. Adv., Volume 9, Issue 22, Jun 2023 | https://doi.org/10.1126/sciadv.adh1765 Fluorescent-based biodegradable microneedle sensor array for tether-free continuous glucose monitoring with smartphone application

Mingyu Sang ^1†, Myeongki Cho ^1†, Selin Lim ^1,2†, In Sik Min ^1†, Yuna Han ^3,4, Chanwoo Lee ¹, Jongwoon Shin ¹, Kukro Yoon ⁵, Woon-Hong Yeo ⁶, Taeyoon Lee ⁵, Sang Min Won ⁷,Youngmee Jung ^2,8*, Yun Jung Heo ^3,4*, Ki Jun Yu ^1,2*

¹Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
²Department of Electrical and Electronic Engineering, YU-Korea Institute of Science and Technology (KIST) Institute, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul03722, Republic of Korea.
³Department of Mechanical Engineering, KyungHee University, 1732 Deogyeong-daero, Yongin-si, Gyeonggi-do 17104, Republic of Korea.
⁴Integrated Education Institute for Frontier Science & Technology (BK21Four), Kyung Hee University, 1732 Deogyeong-daero, Yongin-si, Gyeonggi-do17104, Republic of Korea.
⁵NanoBio Device Laboratory, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
⁶Bio-Interfaced Translational Nanoengineering Group, GeorgeW. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
⁷Flexible Electronic System Research Group, Department of Electrical and Computer Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do, Republic of Korea.
⁸Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea

†These authors contributed equally to this work.
*Corresponding author: correspondence to Youngmee Jung or Yun Jung Heo or Ki Jun Yu

Abstract

Continuous glucose monitoring (CGM) allows patients with diabetes to manage critical disease effectively and autonomously and prevent exacerbation. A painless, wireless, compact, and minimally invasive device that can provide CGM is essential for monitoring the health conditions of freely moving patients with diabetes. Here, we propose a glucose-responsive fluorescence-based highly sensitive biodegradable microneedle CGM system. These ultrathin and ultralight microneedle sensor arrays continuously and precisely monitored glucose concentration in the interstitial fluid with minimally invasive, pain-free, wound-free, and skin inflammation–free outcomes at various locations and thicknesses of the skin. Bioresorbability in the body without a need for device removal after use was a key characteristic of the microneedle glucose sensor. We demonstrated the potential long-term use of the bioresorbable device by applying the tether-free CGM system, thus confirming the successful detection of glucose levels based on changes in fluorescence intensity. In addition, this microneedle glucose sensor with a user-friendly designed home diagnosis system using mobile applications and portable accessories offers an advance in CGM and its applicability to other bioresorbable, wearable, and implantable monitoring device technology.

논문정보

형식Research article
게재일2023년 06월 (BRIC 등록일 2023-06-02)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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