한빛사논문
- 조회232
Mingle Li 1, Jungryun Kim 1, Hyeonji Rha 1, Subin Son 1, Matthew S Levine 2, Yunjie Xu 1, Jonathan L Sessler 2, Jong Seung Kim 1
1Department of Chemistry, Korea University, Seoul 02841, Korea.
2Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
M.L. and J.K. contributed equally to this work.
Corresponding Authors : Yunjie Xu, Jonathan L. Sessler, Jong Seung Kim
Abstract
Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD) characterized by the release of pro-inflammatory cytokines. Our knowledge of pyroptosis has expanded beyond the cellular level and now includes extracellular responses. In recent years, pyroptosis has attracted considerable attention due to its potential to induce host immunity. For instance, at the 2022 International Medicinal Chemistry of Natural Active Ligand Metal-Based Drugs (MCNALMD) conference, numerous researchers demonstrated an interest in photon-controlled pyroptosis activation ("PhotoPyro"), an emerging pyroptosis-engineered approach for activating systemic immunity via photoirradiation. Given this enthusiasm, we share in this Perspective our views on this emerging area and expound on how and why "PhotoPyro" could trigger antitumor immunity (i.e., turning so-called "cold" tumors "hot"). In doing so, we have tried to highlight cutting-edge breakthroughs in PhotoPyro while suggesting areas for future contributions. By providing insights into the current state of the art and serving as a resource for individuals interested in working in this area, it is hoped that this Perspective will set the stage for PhotoPyro to evolve into a broadly applicable cancer treatment strategy.
논문정보
- Review Paper
- 2023년 03월 (BRIC 등록일 2023-06-02)
- 국내(교신)+국외 연구진
- 의약학 > 분자세포의학
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
