한빛사논문
- 조회178
Nahyun Kwon 1, Gabriel O Jasinevicius 2, Giulia Kassab 1, Lili Ding 1, Jiachuan Bu 1, Letícia P Martinelli 2, Vinicius G Ferreira 3, Alexander Dhaliwal 4, Harley H L Chan 1, Yulin Mo 5, Vanderlei S Bagnato 2, Cristina Kurachi 2, Juan Chen 1, Gang Zheng 6, Hilde H Buzzá 7
1University Health Network, Princess Margaret Cancer Centre, CANADA.
2University of Sao Paulo: Universidade de Sao Paulo, Sao Carlos Institute of Physics, BRAZIL.
3University of Sao Paulo: Universidade de Sao Paulo, Chemistry, BRAZIL.
4University of Toronto, Department of Medical Biophysics, CANADA.
5University of Toronto, Institute of Medical Sciences, CANADA.
6University of Toronto, Princess Margaret Cancer Centre, 101 College St, PMCRT 5-354, Canada, M5G1L7, Toronto, CANADA.
7Pontifical Catholic University of Chile: Pontificia Universidad Catolica de Chile, Institute of Physics, CHILE.
CORRESPONDING AUTHOR : Gang Zheng
Abstract
Indocyanine green (ICG) is the only NIR-dye approved for clinical use. Despite its versatility in photonic applications and potential for photothermal therapy, its photobleaching hinders its application. Here we discovered a nanostructure of dimeric ICG (Nano-dICG) generated by using ICG to stabilize nanoemulsion, after which ICG enabled complete dimerization on the nanoemulsion shell, followed by J-aggregation of ICG-dimer, resulting in a narrow, red-shifted (780nm → 894nm) and intense (~2-fold) absorbance. Compared to ICG, Nano-dICG demonstrated superior photothermal conversion (2-fold higher), significantly reduced photodegradation (-9.6% vs. -46.3%), and undiminished photothermal effect (7 vs. 2 cycles) under repeated irradiations, in addition to excellent colloidal and structural stabilities. Following intravenous injection, Nano-dICG enabled real-time tracking of its delivery to mouse tumor within 24h by photoacoustic imaging at a NIR wavelength (890nm) distinct from the endogenous signal to guide effective photothermal therapy. The unprecedented finding of nanostructure-driven ICG dimerization leads to ultra-stable phototheranostic platform.
논문정보
- Research article
- 2023년 05월 (BRIC 등록일 2023-06-02)
- 국외 연구진
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