상위피인용논문
- 조회514
충남대학교 병원
Ji Sun Moon 1*, Ludger J. E. Goeminne 2*, Jung Tae Kim 1,3*, Jing Wen Tian 1,3, Seok-Hwan Kim 4, Ha Thi Nga 1,3, Seul Gi Kang 1,3, Baeki E. Kang 5, Jin-Seok Byun 6, Young-Sun Lee 7, Jae-Han Jeon 8, Minho Shong 1,3, Johan Auwerx 2, Dongryeol Ryu 5,9,10, Hyon-Seung Yi 1,3
1Research Center for Endocrine and Metabolic Diseases, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Republic of Korea
2Laboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
3Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Republic of Korea
4Department of Surgery, Chungnam National University School of Medicine, Daejeon, Republic of Korea
5Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
6Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea
7Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea
8Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
9Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, Republic of Korea
10Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Republic of Korea
*These authors contributed equally to this work.
Corresponding author: correspondence to Dongryeol Ryu or Hyon-Seung Yi
Abstract
Mitochondrial dysfunction is associated with aging-mediated inflammatory responses, leading to metabolic deterioration, development of insulin resistance, and type 2 diabetes. Growth differentiation factor 15 (GDF15) is an important mitokine generated in response to mitochondrial stress and dysfunction; however, the implications of GDF15 to the aging process are poorly understood in mammals. In this study, we identified a link between mitochondrial stress-induced GDF15 production and protection from tissue inflammation on aging in humans and mice. We observed an increase in serum levels and hepatic expression of GDF15 as well as pro-inflammatory cytokines in elderly subjects. Circulating levels of cell-free mitochondrial DNA were significantly higher in elderly subjects with elevated serum levels of GDF15. In the BXD mouse reference population, mice with metabolic impairments and shorter survival were found to exhibit higher hepatic Gdf15 expression. Mendelian randomization links reduced GDF15 expression in human blood to increased body weight and inflammation. GDF15 deficiency promotes tissue inflammation by increasing the activation of resident immune cells in metabolic organs, such as in the liver and adipose tissues of 20-month-old mice. Aging also results in more severe liver injury and hepatic fat deposition in Gdf15-deficient mice. Although GDF15 is not required for Th17 cell differentiation and IL-17 production in Th17 cells, GDF15 contributes to regulatory T-cell-mediated suppression of conventional T-cell activation and inflammatory cytokines. Taken together, these data reveal that GDF15 is indispensable for attenuating aging-mediated local and systemic inflammation, thereby maintaining glucose homeostasis and insulin sensitivity in humans and mice.
논문정보
- Research article
- 2020년 08월 (BRIC 등록일 2023-05-25)
- 국내(교신)+국외 연구진
- 의약학 > 응용의학
- 60회 이상 인용된 논문
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