한빛사논문
- 조회345
Sangmin Lee a 1, Geunho Choi a 1, Yun Jung Yang b, Kye Il Joo c, Hyung Joon Cha a *
aDepartment of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea
bDepartment of Biological Engineering, Inha University, Incheon 22212, Republic of Korea
cDivision of Chemical Engineering and Materials Science, Ewha Womans University, Seoul 03760, Republic of Korea
1These two authors contributed equally to this work.
*Corresponding authors: Correspondence to Hyung Joon Cha
Abstract
While the natural carbohydrate alginate has enabled effective three-dimensional (3D) extrusion bioprinting, it still suffers from some issues such as low printability and resolution and limited cellular function due to ionic crosslinking dependency. Here, we prepared a harmless visible light-based photocrosslinkable alginate by chemically bonding tyrosine-like residues onto alginate chains to propose a new microgel manufacturing system for the development of 3D-printed bioinks. The photocrosslinkable tyramine-conjugated alginate microgel achieved both higher cell viability and printing resolution compared to the bulk gel form. This alginate-based jammed granular microgel bioink showed excellent 3D bioprinting ability with maintained structural stability. As a biocompatible material, the developed multiple cell-loaded photocrosslinkable alginate-based microgel bioink provided excellent proliferation and migration abilities of laden living cells, providing an effective strategy to construct implantable functional artificial organ structures for 3D bioprinting-based tissue engineering.
논문정보
- Research article
- 2023년 04월 (BRIC 등록일 2023-05-19)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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