김선미 (서울대학교 병원) | 한빛사논문 > 한빛사

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김선미Sunmie Kim

서울대학교 병원

Am. J. Obstet. Gynecol., 5 April 2023 | https://doi.org/10.1016/j.ajog.2023.03.041 Alcohol consumption and the risk of new-onset uterine leiomyomas: a nationwide population-based study in 2.5 million Korean women aged 20 to 39 years

Sunmie Kim MD, PhD ^a, Kyungdo Han PhD ^b, Su-Yeon Choi MD, PhD ^c, Sun Young Yang MD, PhD ^d, Seung Ho Choi MD, PhD ^d, Jeong Yoon Yim MD, PhD ^d, Jin Ju Kim MD, PhD ^a, Min-Jeong Kim MD ^e

^aDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea
^bDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea
^cDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea
^dDepartment of Internal Medicine and Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea
^eDepartment of Obstetrics and Gynecology, CHA Hospital Ilsan Medical Center, Goyang, Republic of Korea

Corresponding author: Seung Ho Choi, MD, PhD.
Sunmie Kim and Kyungdo Han share first authorship.

Abstract

Background
Uterine leiomyomas are the most common benign tumors in women of childbearing age. Although there are several studies reporting the positive association of drinking alcohol with the incidence of uterine leiomyomas, studies targeting Korean women are lacking.

Objective
This study aimed to investigate the association between alcohol consumption and the risk of new-onset uterine leiomyomas in Korean women of early reproductive-age.

Study Design
This was a retrospective nationwide population-based cohort study using the Korean National Health Insurance Service database. Participants comprised 2,512,384 asymptomatic Korean women aged 20 to 39 years who underwent a national health examination from 2009 to 2012. The follow-up period was from the date of the first national health examination to the date of diagnosis of new-onset uterine leiomyomas or December 2018 if no uterine leiomyomas were detected. The diagnosis of uterine leiomyomas required 2 outpatient records within a year or 1 inpatient record of International Classification of Diseases, Tenth Revision (ICD-10) codes of uterine leiomyomas (D25) in the Korean National Health Insurance Service. Exclusion criteria were previously diagnosed uterine leiomyomas during the screening period (January 2002 to the date of first health examination) or uterine leiomyoma diagnosis within 1 year of baseline examination. The associations of alcohol consumption, amount drunk per drinking session, and sustained drinking over time with the risk of new-onset uterine leiomyomas were investigated.

Results
Approximately 6.1% of women aged 20 to 39 years were diagnosed with uterine leiomyomas after an average of 4.3 years. Alcohol consumption was associated with an increased incidence of new-onset uterine leiomyomas of 12% to 16% (hazard ratio, 1.12; 95% confidence interval, 1.11–1.14 for mild-to-moderate drinkers; hazard ratio, 1.16; 95% confidence interval, 1.12–1.20 for heavy drinkers). Drinking ≥1 days per week was associated with increased risk of uterine leiomyomas (hazard ratio, 1.11; 95% confidence interval, 1.10–1.12 for drinking 1 day per week; hazard ratio, 1.15; 95% confidence interval, 1.12–1.17 for drinking ≥3 days per week), and the association increased proportionately to the amount of alcohol consumed per drinking session (hazard ratio, 1.17; 95% confidence interval, 1.15–1.19 for ≥7 glasses per drinking session). Women who also reported alcohol consumption in the questionnaire administered 2 years later (sustained drinkers) exhibited a 20% increased risk of new-onset uterine leiomyomas (hazard ratio, 1.20; 95% confidence interval, 1.17–1.22) compared with women who answered that they did not drink alcohol at both times (sustained nondrinkers). In women who discontinued drinking, the risk was 3% (hazard ratio, 1.03; 95% confidence interval, 1.01–1.06), whereas in women who became drinkers, the risk was 14% (hazard ratio, 1.14; 95% confidence interval, 1.11–1.16).

Conclusion
Having an alcohol drinking habit, the amount of alcohol consumed per drinking session, and sustained drinking over 2 years were significantly associated with the risk of new-onset uterine leiomyomas. Avoiding or discontinuing drinking could lower the risk of new-onset uterine leiomyomas in early reproductive-age women.

논문정보

형식Research article
게재일2023년 04월 (BRIC 등록일 2023-06-02)
연구진국내 연구진
분야 의약학 > 응용의학

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