한빛사논문
- 조회334
Dongkyu Kang1,9, Hyung Shik Kim2,9, Soohyun Han3, Yeonju Lee4, Young-Pil Kim3,4,5,6, Dong Yun Lee2,5,7,8 & Joonseok Lee1,6
1Department of Chemistry, Hanyang University, Seoul 04763, Republic of Korea.
2Department of Bioengineering, College of Engineering, and BK FOUR Biopharmaceutical Innovation Leader for Education and Research Group, Hanyang University, Seoul 04763, Republic of Korea.
3Department of HY-KIST BioConvergence, Hanyang University, Seoul 04763, Republic of Korea.
4Department of Life Science, Hanyang University, Seoul 04763, Republic of Korea.
5Institute of Nano Science and Technology (INST), Hanyang University, Seoul 04763, Republic of Korea.
6Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Republic of Korea.
7Institute for Bioengineering and Biopharmaceutical Research (IBBR), Hanyang University, Seoul 04763, Republic of Korea.
8Elixir Pharmatech Inc., Seoul 07463, Republic of Korea.
9These authors contributed equally: Dongkyu Kang, Hyung Shik Kim.
Corresponding authors : Correspondence to Dong Yun Lee or Joonseok Lee.
Abstract
Owing to the strong absorption of water in the near-infrared (NIR) region near 1.0 μm, this wavelength is considered unsuitable as an imaging and analytical signal in biological environments. However, 1.0 μm NIR can be converted into heat and used as a local water-molecular heating strategy for the photothermal therapy of biological tissues. Herein, we describe a Nd-Yb co-doped nanomaterial (water-heating nanoparticles (NPs)) as strong 1.0 μm emissive NPs to target the absorption band of water. Furthermore, introducing Tm ions into the water-heating NPs improve the NIR lifetime, enabling the development of a NIR imaging-guided water-heating probe (water-heating NIR NPs). In the glioblastoma multiforme male mouse model, tumor-targeted water-heating NIR NPs reduce the tumor volume by 78.9% in the presence of high-resolution intracranial NIR long-lifetime imaging. Hence, water-heating NIR NPs can be used as a promising nanomaterial for imaging and photothermal ablation in deep-tissue-bearing tumor therapy.
논문정보
- Research article
- 2023년 05월 (BRIC 등록일 2023-05-17)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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