한빛사논문
- 조회600
Hyun Jeong Ju, MD, PhD1; Ju Yeong Lee, MD2; Ju Hee Han, MD3; Ji Hae Lee, MD, PhD1; Jung Min Bae MD, PhD1; Solam Lee, MD, PhD2
1Department of Dermatology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea;
2Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;
3Department of Dermatology, Seoul St. Mary's Hospital College of Medicine, The Catholic University of Korea;
Corresponding Author: Solam Lee, MD, PhD
Abstract
Background
Data on the association between the development of autoimmune diseases and coronavirus disease 2019 (COVID-19) vaccination are limited.
Objective
To investigate the incidence and risk of autoimmune connective tissue disorders following mRNA-based COVID-19 vaccination.
Methods
This nationwide population-based study was conducted in South Korea. Individuals who received vaccination between September 8, 2020–December 31, 2021, were identified. Historical pre-pandemic controls were matched for age and sex in 1:1 ratio. The incidence rate and risk of disease outcomes were compared.
Results
A total of 3,838,120 vaccinated individuals and 3,834,804 controls without evidence of COVID-19 were included. The risk of alopecia areata, alopecia totalis, primary cicatricial alopecia, psoriasis, vitiligo, anti-neutrophil cytoplasmic antibody-associated vasculitis, sarcoidosis, Behcet disease, Crohn disease, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjogren syndrome, ankylosing spondylitis, dermato/polymyositis, and bullous pemphigoid was not significantly higher in vaccinated individuals than in controls. The risk was comparable according to age, sex, type of mRNA-based vaccine, and cross-vaccination status.
Limitations
Possible selection bias and residual confounders.
Conclusion
These findings suggest that most autoimmune connective tissue disorders are not associated with a significant increase in risk. However, caution is necessary when interpreting results for rare outcomes due to limited statistical power.
논문정보
- Research article
- 2023년 05월 (BRIC 등록일 2023-05-16)
- 국내 연구진
- 의약학 > 응용의학
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