한빛사논문
- 조회323
Taehee Kim M.D. 1 ∗, Hayoung Choi M.D., Ph.D. 1 ∗, Hyun Lee M.D., Ph.D. 2 ∗, Kyungdo Han Ph.D. 3, Dong Won Park M.D., Ph.D. 2, Tai Sun Park M.D., Ph.D. 2, Ji-Yong Moon M.D., Ph.D. 2, Tae-Hyung Kim M.D., Ph.D. 2, Jang Won Sohn M.D., Ph.D. 2, Ho Joo Yoon M.D., Ph.D. 2, Sang-Heon Kim M.D., Ph.D. 2
1Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea
2Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
3Department of Statistics and Actuarial Science, Soongsil University, Seoul, South Korea
∗These three authors equally contributed to this work.
Correspondence: Sang-Heon Kim, M.D., Ph.D.
Abstract
Background
The association between allergic diseases and the risk of mycobacterial disease is unclear.
Objective
To evaluate the association between allergic diseases and mycobacterial diseases.
Methods
This was a population-based cohort study of 3,838,680 individuals, without prior mycobacterial disease, who participated in the 2009 National Health Screening Exam. We evaluated the prevalence of mycobacterial disease (tuberculosis [TB] or non-tuberculous mycobacterial infection) in participants with allergic disease (asthma, allergic rhinitis, or atopic dermatitis) and those without allergic disease. We followed the cohort up until the date of mycobacterial disease diagnosis, follow-up loss, death, or December 2018.
Results
During a median follow-up of 8.3 (interquartile range, 8.1–8.6) years, 0.6% of participants developed mycobacterial disease. The prevalence of mycobacterial disease was significantly higher in those with allergic diseases than in those without allergic diseases (1.0 vs. 0.7/1,000 person-years, p < 0.001), with an adjusted hazard ratio (aHR) of 1.13 (95% confidence interval [CI], 1.10–1.17). Asthma (aHR [95% CI], 1.37 [1.29–1.45]) and allergic rhinitis (aHR [95% CI], 1.07 [1.04–1.11]) increased the hazard of mycobacterial disease, whereas atopic dermatitis did not. The association between allergic diseases and hazard of mycobacterial disease was more prominent in older (age ≥ 65 years, p for interaction = 0.012) and obese (body mass index ≥ 25 kg/m2, p for interaction < 0.001) participants.
Conclusion
Allergic diseases including asthma and allergic rhinitis were associated with an increased risk of mycobacterial disease, whereas atopic dermatitis was not.
논문정보
- Research article
- 2023년 05월 (BRIC 등록일 2023-05-12)
- 국내 연구진
- 의약학 > 응용의학
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