한빛사논문
- 조회193
부경대학교
Parveen Kumar 1, Seon-Hwa Kim 2, Sonyabapu Yadav 3, Sung-Han Jo 2, Seong Yoo 4, Sang-Hyug Park 2, Kwon Taek Lim 1,3
1Department of Display Engineering, Pukyong National University, Busan 48513, South Korea.
2Department of Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, South Korea.
3Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, South Korea.
4Department of Polymer Engineering, Pukyong National University, Busan 48513, South Korea.
P.K. and S.-H.K. contributed equally.
Corresponding Authors: Sang-Hyug Park, Kwon Taek Lim
Abstract
The physiological instability of nanocarriers, premature drug leakage during blood circulation, and associated severe side effects cause compromised therapeutic efficacy, which have significantly hampered the progress of nanomedicines. The cross-linking of nanocarriers while keeping the effectiveness of their degradation at the targeted site to release the drug has emerged as a potent strategy to overcome these flaws. Herein, we have designed novel (poly(ethylene oxide))2-b-poly(furfuryl methacrylate) ((PEO2K)2-b-PFMAnk) miktoarm amphiphilic block copolymers by coupling alkyne-functionalized PEO (PEO2K-C≡H) and diazide-functionalized poly(furfuryl methacrylate) ((N3)2-PFMAnk) via click chemistry. (PEO2K)2-b-PFMAnk self-assembled to form nanosized micelles (mikUCL) with hydrodynamic radii in the range of 25∼33 nm. The hydrophobic core of mikUCL was cross-linked by a disulfide-containing cross-linker using the Diels-Alder reaction to avoid unwanted leakage and burst release of a payload. As expected, the resulting core-cross-linked (PEO2K)2-b-PFMAnk micelles (mikCCL) exhibited superior stability under a normal physiological environment and were de-cross-linked to rapidly release doxorubicin (DOX) upon exposure to a reduction environment. The micelles were compatible with HEK-293 normal cells, while DOX-loaded micelles (mikUCL/DOX and mikCCL/DOX) induced high antitumor activity in HeLa and HT-29 cells. mikCCL/DOX preferentially accumulated at the tumor site and was more efficacious than free DOX and mikUCL/DOX for tumor inhibition in HT-29 tumor-bearing nude mice.
논문정보
- Research article
- 2023년 03월 (BRIC 등록일 2023-06-14)
- 국내 연구진
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