한빛사논문
- 조회366
Quan Truong Hoang 1, Kim Anh Huynh 2, Thuy Giang Nguyen Cao 1, Ji Hee Kang 3, Xuan Nghia Dang 2, Vasanthan Ravichandran 1, Han Chang Kang 4, Minjong Lee 5, Jong-Eun Kim 6, Young Tag Ko 3, Tae Il Lee 2, Min Suk Shim 1
1Department of Nano-Bioengineering, Incheon National University, Incheon, 22012, Republic of Korea.
2Department of Materials Science and Engineering, Gachon University, Seongnam, Gyeonggi-Do, 13306, Republic of Korea.
3College of Pharmacy, Gachon University, Incheon, 21936, Republic of Korea.
4Department of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences and BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy, College of Pharmacy, The Catholic University of Korea, Gyeonggi-do, 14662, Republic of Korea.
5Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, 07804, Republic of Korea.
6Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, 03722, Republic of Korea.
Q.T.H., K.A.H., and T.G.N.C. authors contributed equally to this work.
CORRESPONDING AUTHORS: Tae Il Lee, Min Suk Shim
Abstract
Piezoelectric nanomaterials that can generate reactive oxygen species (ROS) by piezoelectric polarization under an external mechanical force have emerged as an effective platform for cancer therapy. In this study, piezoelectric 2D WS2 nanosheets are functionalized with mitochondria-targeting triphenylphosphonium (TPP) for ultrasound (US)-triggered, mitochondria-targeted piezodynamic cancer therapy. In addition, a glycolysis inhibitor (FX11) that can inhibit cellular energy metabolism is loaded into TPP- and poly(ethylene glycol) (PEG)-conjugated WS2 nanosheet (TPEG-WS2 ) to potentiate its therapeutic efficacy. Upon US irradiation, the sono-excited electrons and holes generated in the WS2 are efficiently separated by piezoelectric polarization, which subsequently promotes the production of ROS. FX11-loaded TPEG-WS2 (FX11@TPEG-WS2 ) selectively accumulates in the mitochondria of human breast cancer cells. In addition, FX11@TPEG-WS2 effectively inhibits the production of adenosine triphosphate . Thus, FX11@TPEG-WS2 exhibits outstanding anticancer effects under US irradiation. An in vivo study using tumor-xenograft mice demonstrates that FX11@TPEG-WS2 effectively accumulated in the tumors. Its tumor accumulation is visualized using in vivo computed tomography . Notably, FX11@TPEG-WS2 with US irradiation remarkably suppresses the tumor growth of mice without systemic toxicity. This study demonstrates that the combination of piezodynamic therapy and energy metabolism-targeted chemotherapy using mitochondria-targeting 2D WS2 is a novel strategy for the selective and effective treatment of tumors.
논문정보
- Research article
- 2023년 05월 (BRIC 등록일 2023-05-23)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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