한빛사논문
- 조회383
Seong Uk Son 1,2, Soojin Jang 1,2, Jaewoo Lim 1, Seung Beom Seo 1,3, Taejoon Kang 1,4, Juyeon Jung 1,4, Seo Yeong Oh 1, Sun-Woo Yoon 5, Dongeun Yong 6, Jaejong Lee 7, Eun-Kyung Lim 1,2,4
1Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
2Department of Nanobiotechnology, KRIBB School of Biotechnology, University of Science and Technology (UST), Daejeon 34113, Republic of Korea.
3Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, Republic of Korea.
4School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
5Department of Biological Sciences and Biotechnology, Andong National University, Andong 36729, Republic of Korea.
6Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seodaemun-gu, Seoul 03722, Republic of Korea.
7Department of Nano Manufacturing Technology, Korea Institute of Machinery and Materials (KIMM), Daejeon 34103, Republic of Korea.
Corresponding Author : Eun-Kyung Lim
Abstract
Infectious agents such as viruses pose significant threats to human health, being transmitted via direct contact as well as airborne transmission without direct contact, thus requiring rapid detection to prevent the spread of infectious diseases. In this study, we developed a conductive thread-based immunosensor (CT-IS), a biosensor to easily detect the presence of airborne viruses. CT-IS utilizes an antibody that specifically recognizes the HA protein of the pandemic influenza A (pH1N1) virus, which is incorporated into the conductive thread. The antigen-antibody interaction results in increased strain on the conductive thread in the presence of the pH1N1 virus, resulting in increased electrical resistance of the CT-IS. We evaluated the performance of this sensor using the HA protein and the pH1N1 virus, in addition to samples from patients infected with the pH1N1 virus. We observed a significant change in resistance in the pH1N1-infected patient samples (positive: n = 11, negative: n = 9), whereas negligible change was observed in the control samples (patients not infected with the pH1N1 virus; negative). Hence, the CT-IS is a lightweight fiber-type sensor that can be used as a wearable biosensor by combining it with textiles, to detect the pH1N1 virus in a person's vicinity.
논문정보
- Research article
- 2023년 02월 (BRIC 등록일 2023-06-14)
- 국내 연구진
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