한빛사논문
- 조회507
Se-Ra Park1,2†, Myung Geun Kook1,2†, Soo-Rim Kim1,2, Jin Woo Lee1,2, Chan Hum Park3, Byung-Chul Oh4, YunJae Jung5 and In-Sun Hong1,2*
1Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of Korea
2Department of Molecular Medicine, School of Medicine, Gachon University, 7-45 Songdo-dong, Yeonsu-ku, Incheon 406-840, Republic of Korea
†Se-Ra Park and Myung Geun Kook contributed equally to this work.
*Correspondence: In-Sun Hong
Abstract
Background
The endometrium, the inner lining of the uterine cavity, plays essential roles in embryo implantation and its subsequent development. Although some positive results were preliminarily archived, the regeneration of damaged endometrial tissues by administrating stem cells only is very challenging due to the lack of specific microenvironments and their low attachment rates at the sites of injury. In this context, various biomaterial-based scaffolds have been used to overcome these limitations by providing simple structural support for cell attachment. However, these scaffold-based strategies also cannot properly reflect patient tissue-specific structural complexity and thus show only limited therapeutic effects.
Method
Therefore, in the present study, we developed a customizable Lego-like multimodular endometrial tissue architecture by assembling individually fabricated tissue blocks.
Results
Each tissue block was fabricated by incorporating biodegradable biomaterials and certain endometrial constituent cells. Each small tissue block was effectively fabricated by integrating conventional mold casting and 3D printing techniques. The fabricated individual tissue blocks were properly assembled into a larger customized tissue architecture. This structure not only properly mimics the patient-specific multicellular microenvironment of the endometrial tissue but also properly responds to key reproductive hormones in a manner similar to the physiological functions.
Conclusion
This customizable modular tissue assembly allows easy and scalable configuration of a complex patient-specific tissue microenvironment, thus accelerating various tissue regeneration procedures.
논문정보
- Research article
- 2023년 04월 (BRIC 등록일 2023-04-24)
- 국내 연구진
- 의약학 > 재생의학
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
