한빛사논문
- 조회306
Hyunju Yon 1, Hyoin Shin 1, Jae Il Shin 2, Jung U Shin 3, Youn Ho Shin 4, Jinseok Lee 5, Sang Youl Rhee 6,7, Ai Koyanagi 8,9, Louis Jacob 8,10, Lee Smith 11, Seung Won Lee 12, Masoud Rahmati 13, Suhana Ahmad 14, Wonyoung Cho 6, Dong Keon Yon 6,15,16
1Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
2Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea.
3Department of Dermatology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea.
4Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, South Korea.
5Department of Biomedical Engineering, Kyung Hee University, Yongin, South Korea.
6Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
7Department of Endocrinology and Metabolism, Kyung Hee University College of Medicine, Seoul, South Korea.
8Research and Development Unit, CIBERSAM, ISCIII, Barcelona, Spain.
9Catalan Institution for Research and Advanced Studies (ICREA), Pg. Lluis Companys, Barcelona, Spain.
10Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.
11Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
12Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, South Korea.
13Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
14Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
15Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
16Department of Regulatory Science, Kyung Hee University, Seoul, South Korea.
Hyunju Yon, Hyoin Shin and Jae Il Shin are contributed equally.
CORRESPONDING AUTHORS: Wonyoung Cho, Dong Keon Yon
Abstract
Little is known about the ongoing monkeypox (mpox) outbreak, and the clinical features of mpox in patients worldwide have not been rigorously analysed. Thus, we aimed to investigate the clinical features associated with mpox infection and understand the pathophysiology and characteristics of the disease. For this systematic review and meta-analysis, we searched PubMed/MEDLINE, Embase, CINAHL, Google Scholar, and the Cochrane Database of Systematic Reviews for articles published till 16 September 2022. We used a random effects model to calculate the pooled prevalence and 95% confidence interval (CI). We used the I2 statistic to assess heterogeneity, Egger's test to assess publication bias, 95% prediction interval to determine the level of uncertainty, and the Newcastle-Ottawa Scale and Joanna Briggs Institute quality assessment tool to assess the risk of bias. Twenty-six relevant articles from 19 countries across 5 continents were included, and data on 5472 mpox patients with 18 unique features were analysed. The pooled prevalence of clinical features of mpox were rash (85.7%, 95% CI: 68.3-94.3; k = 21), chills (77.8%, 95% CI: 70.5-83.7; k = 3), and fever (62.3%, 95% CI: 51.3-71.6; k = 25), lymphadenopathy (58.6%, 95% CI: 47.2-69.2; k = 21), lethargy or exhaustion (46.8%, 95% CI: 30.7-63.5; k = 14), pruritus (40.6%, 95% CI: 28.5-54.0; k = 5), myalgia (36.0%, 95% CI: 24.3-49.7; k = 16), headache (34.6%, 95% CI: 23.4-47.8; k = 17), skin ulcer (31.1%, 95% CI: 18.6-47.1; k = 7), abdomen symptom (24.2%, 95% CI: 17.9-31.9; k = 11), pharyngitis (23.0%, 95% CI: 12.7-37.9; k = 14), respiratory symptom (19.5%, 95% CI: 6.8-44.6; k = 6), nausea or vomiting (13.0%, 95% CI: 4.6-31.9; k = 3), scrotal or penile oedema (10.7%, 95% CI: 6.3-17.7; k = 4), conjunctivitis (7.1%, 95% CI: 2.4-18.9; k = 6), and death (0.9%, 95% CI: 0.4-2.0; k = 26). This is the first international and comprehensive study to examine all clinical presentations of human mpox infection. Our systematic review proposes a comprehensive understanding of the current mpox outbreak and may serve as key data for future studies on the pathological mechanisms and epidemiology of mpox infections.
논문정보
- Review Paper
- 2023년 04월 (BRIC 등록일 2023-04-17)
- 국내(교신)+국외 연구진
- 의약학 > 응용의학
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