한빛사논문
- 조회379
동국대학교
Ganji Seeta Rama Raju1, Eluri Pavitra2, Sai Samyuktha Bandaru3, Ganji Lakshmi Varaprasad2, Ganji Purnachandra Nagaraju4*, Rama Rao Malla5*, Yun Suk Huh2* and Young-Kyu Han1*
1Department of Energy and Materials Engineering, Dongguk University–Seoul, Seoul 04620, Republic of Korea
2NanoBio High-Tech Materials Research Center, Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea
3Baton Rouge General Hospital, Baton Rouge LA-70809, USA
4School of Medicine, Division of Hematology and Oncology, University of Alabama, Birmingham, AL 35233, USA
5Cancer Biology Laboratory, Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh 530045, India
*Correspondence: Ganji Purnachandra Nagaraju, Rama Rao Malla, Yun Suk Huh, Young-Kyu Han
Abstract
HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.
논문정보
- Review Paper
- 2023년 03월 (BRIC 등록일 2023-04-12)
- 국내(교신)+국외 연구진
- 생명과학 > 생물공학
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