한빛사논문
- 조회359
Byungju Kim1,4, Jincheol Seol2,4, Yoon Ki Kim3 and Jong-Bong Lee1,2
1Department of Physics, Pohang University of Science & Technology (POSTECH), Pohang 37673, Republic of Korea.
2School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang 37673, Republic of Korea.
3Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
4These authors contributed equally: Byungju Kim, Jincheol Seol.
Corresponding author: Jong-Bong Lee
Abstract
Translation is mediated by precisely orchestrated sequential interactions among translation initiation components, mRNA, and ribosomes. Biochemical, structural, and genetic techniques have revealed the fundamental mechanism that determines what occurs and when, where and in what order. Most mRNAs are circularized via the eIF4E-eIF4G-PABP interaction, which stabilizes mRNAs and enhances translation by recycling ribosomes. However, studies using single-molecule fluorescence imaging have allowed for the visualization of complex data that opposes the traditional "functional circularization" theory. Here, we briefly introduce single-molecule techniques applied to studies on mRNA circularization and describe the results of in vitro and live-cell imaging. Finally, we discuss relevant insights and questions gained from single-molecule research related to translation.
논문정보
- Review Paper
- 2023년 02월 (BRIC 등록일 2023-04-07)
- 국내 연구진
- 생명과학 > 유전학
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