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The Hospital for Sick Children

Neuron, Published:March 28, 2023 | https://doi.org/10.1016/j.neuron.2023.03.007 Examining the engram encoding specificity hypothesis in mice

Jung Hoon Jung,¹ Ying Wang,^1,2 Andrew J. Mocle,^1,2 Tao Zhang,¹ Stefan Ko¨ hler,^3,4 Paul W. Frankland,^1,2,5,6 and Sheena A. Josselyn^1,2,5,7,*

¹Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada
²Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada
³Department of Psychology, University of Western Ontario, London, ON N6A 5C2, Canada
⁴The Brain and Mind Institute, University of Western Ontario, London, ON N6A 3K7, Canada
⁵Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada
⁶Child & Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, ON M5G 1M1, Canada
⁷Lead contact

^*Correspondence: Sheena A. Josselyn

Abstract

According to the encoding specificity hypothesis, memory is best recalled by retrieval cues that overlap with training cues. Human studies generally support this hypothesis. However, memories are thought to be stored in neuronal ensembles (engrams), and retrieval cues are thought to reactivate neurons in an engram to induce memory recall. Here, we visualized engrams in mice to test whether retrieval cues that overlap with training cues produce maximal memory recall via high engram reactivation (engram encoding specificity hypothesis). Using variations of cued threat conditioning (pairing conditioned stimulus [CS] with footshock), we manipulated encoding and retrieval conditions along multiple domains, including pharmacological state, external sensory cue, and internal optogenetic cue. Maximal engram reactivation and memory recall occurred when retrieval conditions closely matched training conditions. These findings provide a biological basis for the encoding specificity hypothesis and highlight the important interaction between stored information (engram) and cues available at memory retrieval (ecphory).

논문정보

형식Research article
게재일2023년 03월 (BRIC 등록일 2023-04-07)
연구진국외 연구진
분야 생명과학 > 신경생물학

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