한빛사논문
- 조회293
Junhua Xu1,9,10, Hongwei Cai1,10, Zhuhao Wu1, Xiang Li1, Chunhui Tian1, Zheng Ao1, Vivian C. Niu1,2, Xiao Xiao3, Lei Jiang1, Marat Khodoun4, Marc Rothenberg4, Ken Mackie5, Jun Chen3, Luke P. Lee6,7,8 & Feng Guo1
1Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN 47405, USA.
2Bloomington High School South, Bloomington, IN 47401, USA.
3Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
4Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
5Gill Center for Biomolecular Science, and Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA.
6Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
7Department of Bioengineering, Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720, USA.
8Institute of Quantum Biophysics, Department of Biophysics, Sungkyunkwan University, Suwon, Korea.
9Present address: Biopharmaceutical Research Institute, West China Hospital, Sichuan University, Chengdu 610041 Sichuan, China.
10These authors contributed equally: Junhua Xu, Hongwei Cai
Corresponding authors : Correspondence to Jun Chen, Luke P. Lee or Feng Guo.
Abstract
Transdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute diseases mainly due to their inability to timely administrate therapeutics and precisely regulate pharmacokinetics within a short time window. Here we report the development of active acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand acute disease management. Through the integration of active acoustic metamaterials, a compact therapeutic patch is integrated for penetration of skin stratum corneum and active percutaneous transport of therapeutics with precise control of dose and rate over time. Moreover, the patch device quantitatively regulates the dosage and release kinetics of therapeutics and achieves better delivery performance in vivo than through subcutaneous injection. As a proof-of-concept application, we show our method can reverse life-threatening acute allergic reactions in a female mouse model of anaphylaxis via a multi-burst delivery of epinephrine, showing better efficacy than a fixed dosage injection of epinephrine, which is the current gold standard 'self-injectable epinephrine' strategy. This innovative method may provide a promising means to manage acute disease for personalized medicine.
논문정보
- Research article
- 2023년 02월 (BRIC 등록일 2023-04-05)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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