한빛사논문
- 조회626
Taehong Yang 1, Daniel W. Bayless 1, Yichao Wei 1, Dan Landayan 1, Ivo M. Marcelo 6,7, Yangpeng Wang 1, Laura A. DeNardo 4,5,8, Liqun Luo 4,5, Shaul Druckmann 1,2, Nirao M. Shah 1,2,3,9
1Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA
2Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
3Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305, USA
4Department of Biology, Stanford University, Stanford, CA 94305, USA
5Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
6Champalimaud Neuroscience Program, Champalimaud Center for the Unknown, 1400-038 Lisbon, Portugal
7Department of Psychiatry, Erasmus MC University Medical Center, 3015 GD Rotterdam, the Netherlands
8Present address: Department of Physiology, University of California Los Angeles, Los Angeles, CA 90095, USA
9Lead contact
Corresponding author: Nirao M. Shah
Abstract
Social interactions require awareness and understanding of the behavior of others. Mirror neurons, cells representing an action by self and others, have been proposed to be integral to the cognitive substrates that enable such awareness and understanding. Mirror neurons of the primate neocortex represent skilled motor tasks, but it is unclear if they are critical for the actions they embody, enable social behaviors, or exist in non-cortical regions. We demonstrate that the activity of individual VMHvlPR neurons in the mouse hypothalamus represents aggression performed by self and others. We used a genetically encoded mirror-TRAP strategy to functionally interrogate these aggression-mirroring neurons. We find that their activity is essential for fighting and that forced activation of these cells triggers aggressive displays by mice, even toward their mirror image. Together, we have discovered a mirroring center in an evolutionarily ancient region that provides a subcortical cognitive substrate essential for a social behavior.
논문정보
- Research article
- 2023년 03월 (BRIC 등록일 2023-04-05)
- 국외 연구진
- 생명과학 > 생리학
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